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Category:Primary Innate Immunity Deficiencies (view source)
Revision as of 13:45, 12 August 2010
, 13:45, 12 August 2010Created page with "===Deficiencies of Innate Immunity=== [[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melto..."
===Deficiencies of Innate Immunity===
[[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton]]
====Canine Cyclic Haematopoiesis====
*Also called '''Grey Collie Syndrome'''
*Autosomal recessive
*Insertion mutation in AP3B1 gene
*Diluted grey coat colour, stunted growth, poor wound healing
*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
**E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis
*Puppies can be distinguished from other litter mates by the diluted grey colouring
*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
*Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth
====Canine Leukocyte Adhesion Deficiency (CLAD)====
*Occurs in Irish Setters
*Missence mutation of -Cys-36-Ser- in CD18 molecule
**CD18 is required for [[Neutrophils|neutrophil]] migration and phagocytosis
*Recurrent bacterial infection
*Neutrophilia ([[Neutrophils|neutrophils]] remain in the blood and are unable to fight infection in the tissue)
====Bovine Leukocyte Adhesion Deficiency (BLAD)====
*Occurs in Holstein cattle
*Missence mutation of -Asp-128-Gly in CD18 molecule
*Recurrent infection, e.g. pneumonia
[[Category:Primary Im
[[Image:Grey Collie Syndrome.jpg|thumb|right|150px|Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton]]
====Canine Cyclic Haematopoiesis====
*Also called '''Grey Collie Syndrome'''
*Autosomal recessive
*Insertion mutation in AP3B1 gene
*Diluted grey coat colour, stunted growth, poor wound healing
*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]
*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
**E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis
*Puppies can be distinguished from other litter mates by the diluted grey colouring
*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
*Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth
====Canine Leukocyte Adhesion Deficiency (CLAD)====
*Occurs in Irish Setters
*Missence mutation of -Cys-36-Ser- in CD18 molecule
**CD18 is required for [[Neutrophils|neutrophil]] migration and phagocytosis
*Recurrent bacterial infection
*Neutrophilia ([[Neutrophils|neutrophils]] remain in the blood and are unable to fight infection in the tissue)
====Bovine Leukocyte Adhesion Deficiency (BLAD)====
*Occurs in Holstein cattle
*Missence mutation of -Asp-128-Gly in CD18 molecule
*Recurrent infection, e.g. pneumonia
[[Category:Primary Im