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− | |backcolour = FFE4E1
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− | |linkpage =Immunology
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− | |linktext =IMMUNOLOGY
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− | |sublink1 =Hypersensitivity - WikiBlood
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− | |subtext1 =HYPERSENSITIVITY
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− | |pagetype =Blood
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| ==Introduction== | | ==Introduction== |
− | [[Image:Sensitisation phase Type IV Hypersensitivity.jpg|right|thumb|150px|Sensitisation phase: Type VI hypersensitivity-Brian Catchpole RVC 2008]] | + | [[Image:Sensitisation phase Type IV Hypersensitivity.jpg|right|thumb|150px|Sensitisation phase: Type IV hypersensitivity-Brian Catchpole RVC 2008]] |
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− | [[Image:Delayed type hypersensitivity.jpg|right|thumb|150px|Type VI hypersensitivity-Brian Catchpole RVC 2008]] | + | [[Image:Delayed type hypersensitivity.jpg|right|thumb|150px|Type IV hypersensitivity-Brian Catchpole RVC 2008]] |
| Cell mediated hypersensitivity: | | Cell mediated hypersensitivity: |
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| | '''Pathogenesis''' | | | '''Pathogenesis''' |
− | | [[Type I Hypersensitivity - WikiBlood|Type I]] | + | | [[Type I Hypersensitivity|Type I]] |
− | | [[Type IV Hypersensitivity - WikiBlood|Type IV]] | + | | [[Type IV Hypersensitivity|Type IV]] |
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| | '''Time''' | | | '''Time''' |
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| * It is used for TB testing cattle; the antigen is purified protein derivative-PPD from [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']]. | | * It is used for TB testing cattle; the antigen is purified protein derivative-PPD from [[:Category:Mycobacterium species|''Mycobacterium tuberculosis'']]. |
| * Presently in the UK the animal is culled if it has a positive skin reaction. | | * Presently in the UK the animal is culled if it has a positive skin reaction. |
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| + | ==From Pathology== |
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| + | *Delayed hypersensitivity |
| + | *Haptens bind to carrier proteins (mainly epidermal) |
| + | *Mediated by sensitised [[T cell differentiation|T-cells]] -> release cytokines +/- recruit lymphocytes |
| + | *Used in diagnosis of tuberculosis, histoplasmosis and coccidiomycosis |
| + | *Perivascular mononuclear cell accumulation |
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| + | <br><br> |
| + | {{Jim Bee 2007}} |
| + | [[Category:Hypersensitivity]] |