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Pregnant women should avoid contact with cats. If contact is unavoidable, pregnant women should at least avoid cleaning cat litter boxes or wear gloves when doing so. Meat should be cooked thoroughly, to a temperature of 165 to 170° F (74 to 77° C), and hands should be washed thoroughly after handling raw meat, soil, or cat litter. Freezing to a temperature of 9° F (13° C ) or below also destroys the parasite.
 
Pregnant women should avoid contact with cats. If contact is unavoidable, pregnant women should at least avoid cleaning cat litter boxes or wear gloves when doing so. Meat should be cooked thoroughly, to a temperature of 165 to 170° F (74 to 77° C), and hands should be washed thoroughly after handling raw meat, soil, or cat litter. Freezing to a temperature of 9° F (13° C ) or below also destroys the parasite.
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Potential organ donors should be tested to prevent the spread of the parasite through transplanted organs. Trimethoprim-sulfamethoxazole Some Trade Names
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Asymptomatic infections in immunocompetent patients do not require treatment.
may be used to prevent toxoplasmosis. People who cannot take this drug may be given pyrimethamine Some Trade Names
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DARAPRIM
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with dapsone Some Trade Names
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ACZONE
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. Another option is atovaquone Some Trade Names
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MEPRON
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with or without pyrimethamine Some Trade Names
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DARAPRIM
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. Because pyrimethamine Some Trade Names
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DARAPRIM
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can damage bone marrow, leucovorin is given with it to help protect the bone marrow. People with AIDS may be given highly active antiretroviral drugs to reduce the risk of toxoplasmosis.
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Infected adults without symptoms and with a healthy immune system do not require treatment. Adults with symptoms and infants with congenital toxoplasmosis are treated with sulfadiazine plus pyrimethamine Some Trade Names
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DARAPRIM
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and leukovorin. Higher does of pyrimethamine Some Trade Names
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DARAPRIM
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are typically used in people with AIDS or other conditions that weaken the immune system. If people cannot take sulfadiazine, clindamycin Some Trade Names
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CLEOCIN
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can be used with pyrimethamine Some Trade Names
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DARAPRIM
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instead. Women who acquire toxoplasmosis during pregnancy may be treated with spiramycin to prevent transmission to the fetus. In addition to these drugs, people with chorioretinitis are given prednisone or another corticosteroid to reduce inflammation. In people with AIDS, toxoplasmosis tends to recur, so drugs are often continued indefinitely.
       
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