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| ===Epidemiology=== | | ===Epidemiology=== |
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− | When ''Culicoides'' feed on a bluetongue-infected host, they become persistently infected with the virus for the duration of their lives<sup>4</sup>. The global distribution of BTV is related only to these competent insect vectors<sup>2</sup>: although vertical and venereal transmission of bluetongue is possible, these routes do not influence the epidemiology of BTV.
| + | Althbough bluetongue virus is capable of infecting any ruminant, cattle are the main amplifying and maintenance hosts, and are fed on most abundantly by ''Culicoides'' vectors. The global distribution of BTV is related only to these competent insect vectors<sup>2</sup>: although vertical and venereal transmission of bluetongue is possible, these routes do not influence the epidemiology of BTV. This is illustrated by the fact that bluetongue virus is limited to geographical areas where competent vectors are present and that transmission only occurs at times of the year when conditions are favourably for vector activity<sup>1</sup> |
− | Althbough bluetongue virus is capable of infecting any ruminant, cattle are the main amplifying and maintenance hosts, and are fed on most abundantly by ''Culicoides'' vectors.
| + | - in Britain, late summer and autumn. When a host becomes infected with BTV, either death ensues or an antibody response is mounted which renders the animal resistant to re-infection. This presents a challenge to persistence of bluetongue virus since animals quickly become "unavailable" for infection, particularly in areas where livestock populations are small. The virus must therefore contintually spread to new locations to find naive hosts |
| + | When ''Culicoides'' feed on a bluetongue-infected host, they become persistently infected with the virus for the duration of their lives<sup>4</sup>. |
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− | | + | . These |
− | 5.2 BTV is limited to those geographical areas where competent Culicoides vectors
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− | are present. Its transmission is limited to those times of the year when the climatic
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− | conditions are favourable for adult vector activity. Peak populations of vector
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− | Culicoides occur in the late summer and autumn and therefore this is the time when
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− | BT is most commonly seen.
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− | 5.3 Persistence of BTV within a particular geographical area does not mean
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− | “static”. Once a vertebrate host is infected with BTV it either dies or mounts an
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− | enduring antibody response and so becomes resistant to further infection. This means
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− | that within any small geographical area (a farm or village) most or all of the initially
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− | susceptible hosts are likely to be infected and thus become “unavailable” to the virus
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− | within a fairly short space of time. BTV can only survive under such constraints by
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− | continually moving to new locations occupied by naïve vertebrate hosts. These
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| movements are via the agency of viraemic hosts or infected vectors. BTV is therefore | | movements are via the agency of viraemic hosts or infected vectors. BTV is therefore |
| a peripatetic virus and even within its enzootic zones its activity may be envisaged as a | | a peripatetic virus and even within its enzootic zones its activity may be envisaged as a |