Changes

===Laboratory Tests===

===Laboratory Tests===

Laboratory tests are unlikely to show abnormalities until 36-72 hours after exposure, due to the delay in onset of haemorrhagic signs. Because factor VII, involved in the extrinsic pathway, has the shortest half-life prothrombin time is generally the first parameter to become prolonged as factor VII is depleted most rapidly.

Laboratory tests are unlikely to show abnormalities until 36-72 hours after exposure, due to the delay in onset of haemorrhagic signs. Prothrombin time (PT) is a measure of functionality of the extrinsic pathway, and because factor VII has the shortest half life and thus becomes depleted most rapidly, this parameter  is generally the first to become prolonged.

 

first factor to become depleted. The partial thromboplastin

The partial thromboplastin

time (PTT) and activated clotting time (ACT) are

time (PTT) and activated clotting time (ACT) are

usually prolonged by 48 to 72 hours post-exposure. The

usually prolonged by 48 to 72 hours post-exposure. The