Changes

===Classification===

===Classification===

Over 60 years ago, the viral aetiology of the disease bovine viral diarrhoea was established. In the 1960s-70s, bovine viral diarrhoea virus (BVDV), together with related agents causing disease in sheep and swine, was assigned to the newly-penned “Pestivirus” genus. At this stage, Pestiviruses were considered to be non-arthropod-borne togaviruses, although it was later realised by sequencing of genomic RNA they are more taxonomically suited to the family Flaviviridae (Collett et al, 1988; Meyers et al, 1989), where they reside today.

The  viral aetiology of BVD was first established over 60 years ago, but it was not until the 1960s that the agent was assigned to the newly penned "Pestivirus" genus. At this stage Pestiviruses were considered to be non-arthropod-borne togaviruses; later, sequencing of genomic RNA showed that they are taxonomically better suited to the Flaviviridae family, as they are classified today^{1, 2}. (Collett et al, 1988; Meyers et al, 1989)

The Flaviviridae are primarily spread via arthropod vectors, particularly mosquitoes and ticks. Genera within the family include the Flaviviruses, which cause disease in both man (such as yellow fever virus and West Nile virus) and animals (for example, louping ill), and Hepacivirus, which contains Hepatitis C virus only.  

The Flaviviridae are primarily spread via arthropod vectors, particularly mosquitoes and ticks. Genera within the family include the Flaviviruses, which cause disease in both man (such as yellow fever virus and West Nile virus) and animals (for example, louping ill), and Hepacivirus, which contains Hepatitis C virus only.