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Equine Severe Combined Immune Deficiency (view source)
Revision as of 22:10, 24 August 2010
, 22:10, 24 August 2010no edit summary
==Description==
==Description==
Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring in 2-3% of Arab or cross-bred Arab foals. About 16-25% of Arabian horses are carriers of the disease. SCID is characterised by a complete absence of functional B and T lymphocytes and affected (homozygous) foals fail to produce antigen-specific immune responses. The disease results in the absence of a functional immune system and affected foals are unable to resist or recover from infections. In
Severe combined immunodeficiency disease (SCID) of horses is an autosomal, recessive hereditary disease occurring in 2-3% of Arab or cross-bred Arab foals. About 16-25% of Arabian horses are carriers of the disease. SCID is characterised by a complete absence of functional B and T lymphocytes and affected (homozygous) foals fail to produce antigen-specific immune responses. The disease results in the absence of a functional immune system and affected foals are unable to resist or recover from infections.
The most common opportunistic infections in affected foals are pneumonia caused by viral (Adenovirus), bacterial (Rhodococcus equi), fungal (Pneumocystis carinii) or protozoal (Cryptosporidium) organisms.
==Signalment==
==Signalment==