Changes

===Microfilaricidal Treatment===

===Microfilaricidal Treatment===

 

weeks after successful adulticidal treatment. There are

No drugs are specifically approved for microfilaricidal treatment of ''Dirofilaria immitis'', and successful elimination of adult worms should results in the demise of circulating microfilariae four to six weeks later². A single doses of ivermectin, milbemycin oxime, moxidection or selamectin are, however, effective at removing microfilariae from the circulation. The sudden death of large numbers of microfilariae may invoke an anaphylactic response, and oral prednisolone may be administered with microfilaricides to help prevent this.

no approved drugs for microfilaricidal treatment. However,

a single administration of ivermectin (50 jig/kg)

or milbemycin oxime (500 jig/kg) has been shown to be

highly effective in eliminating microfilariae from the circulation

within a few hours. Moxidectin and selamectin

reactions which may occur secondarily to the sudden

death of a large number of microfilariae.

===Prevention===  

===Prevention===