Changes

===Endotoxaemia===

===Endotoxaemia===

Endotoxaemia can occur in severe infections by Gram negative bacteria. The toxins produced by the bacteria are thought to induce blood clotting in very small vessels, occluding blood flow and resulting in blood pools in the peripheral tissues. Endotoxaemia is a risk factor for the development of [[Disseminated Intravascular Coagulation|Disseminated Intravascular Coagulation]].

Endotoxaemia can occur in severe infections by Gram negative bacteria. The toxins produced by the bacteria are thought to induce blood clotting in very small vessels, occluding blood flow and resulting in blood pools in the peripheral tissues. Endotoxaemia is a risk factor for the development of [[Disseminated Intravascular Coagulation|disseminated intravascular coagulation (DIC)]].

===Cardiac disruption===

===Cardiac disruption===