Changes

==Actions==

==Actions==

<p>Macrophages are phagocytic and take up particles and cell debris by endocytosis, as well has engulfing pathogens like bacteria. These are then present in the macrophage inside phagosomes. Lysosomes present in the cytoplasm then bind with the phagosome and release their contents which degrade/digest its contents.</p>

<p>Macrophages are phagocytic and take up particles and cell debris by endocytosis, as well has engulfing pathogens like bacteria. These are then present in the macrophage inside phagosomes. Lysosomes present in the cytoplasm then bind with the phagosome and release their contents which degrade/digest its contents.</p>

<p>Macrophages also act as '''antigen presenting cells''' taking antigens to lymph nodes to present to T cells. MHC II (major histocompatibility complex II) proteins on their surface allow them to interact with helper T cells (CD4). Short peptide segments from foreign cells are presented with MHC II which activates the T cell.</p>

<p>Macrophages also act as '''antigen presenting cells''' taking antigens to lymph nodes to present to T cells. MHC II ([[Major Histocompatability Complexes|major histocompatibility complex]] II) proteins on their surface allow them to interact with helper T cells (CD4). Short peptide segments from foreign cells are presented with MHC II which activates the T cell.</p>

<p>To migrate through connective tissue they release proteases and glycoaminoglycanases.</p>

<p>To migrate through connective tissue they release proteases and glycoaminoglycanases.</p>

===Role in pathology===

===Role in pathology===