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[[Image:LH Mast cells Histology.jpg|right|thumb|150px|<p>'''Mast cells'''</p><sup>©Nottingham Uni 2008</sup>]]
[[Image:LH Mast cells Histology.jpg|right|thumb|150px|<p>'''Mast cells'''</p><sup>©Nottingham Uni 2008</sup>]]
==Introduction==
==Introduction==
<p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to [[Basophils|basophils]] they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>
<p>Mast cells are derived from the same stem cell line as [[Basophils|basophils]] and while they are similar to basophils they are not identical. Mast cells are found in connective tissue and are larger than other [[Leukocytes|leukocytes]] at 15-20µm. They have cytoplasm containing a high number of large, intensely staining basophilic granules which mask the nucleus.</p>
==Development==
==Development==
<p>Mast cells CFU develops in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid set cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor. Then under the stimulation of Il-6 and SCF the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by Il-4, and produce their granules. Once in the tissue mast cells may last for weeks to months.</p>
<p>Mast cells CFU develops in the [[Bone Marrow - Anatomy & Physiology|bone marrow]] from the myeloid set cell ([[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]]) under the stimulation of IL-3 and Stem Cell Factor. Then under the stimulation of Il-6 and SCF the immature mast cells are formed. These then enter circulation where they remain undifferentiated. On migration into tissue they then differentiate, under stimulation by Il-4, and produce their granules. Once in the tissue mast cells may last for weeks to months.</p>