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*The MHC II-antigen complex is then secreted to the cell surface for presentation to [[T_cells#Helper_CD4.2B|CD4+ T-cells]]
 
*The MHC II-antigen complex is then secreted to the cell surface for presentation to [[T_cells#Helper_CD4.2B|CD4+ T-cells]]
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=Antigen/MHC Interaction=
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==Antigen/MHC Interaction==
 
* The MHC molecules do not recognise specific amino acid sequences of antigens
 
* The MHC molecules do not recognise specific amino acid sequences of antigens
 
** Instead, they recognise particular motifs of amino acids
 
** Instead, they recognise particular motifs of amino acids
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** E.g. ruminants have no MHC class II DP
 
** E.g. ruminants have no MHC class II DP
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=MHC and Disease=
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==MHC and Disease==
 
* Antigen from a pathogen has to be seen by the host MHC before an efficient immune response can occur
 
* Antigen from a pathogen has to be seen by the host MHC before an efficient immune response can occur
 
** There is therefore a constant evolutionary battle between the host and the pathogen
 
** There is therefore a constant evolutionary battle between the host and the pathogen
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