Changes

|species =''T. suis''             

|species =''T. suis''             

}}

}}

 

Also known as: '''''Trichocephalus suis — Pig Whipworm

| Also known as:

| '''''Trichocephalus suis''<br>Pig Whipworm

===Overview===

===Overview===

===Use in Human Medicine===

===Use in Human Medicine===

In experimental models, ''Trichuris'' markedly increases T-regulatory activity, thereby suppressing some immune-mediated diseases (Th2 responses increased; Th1 responses decreased). There is a theory that some human immune-mediated diseases are largely restricted to affluent developed countries (like inflammatory bowel disease and Crohn's disease) occur because the human immune system has evolved with T-regulating helminths constantly present, and therefore tends to go into overdrive in some individuals if this external regulatory influence is lacking. This had led to the hypothesis that strictly controlled exposure of selected human patients to ''T. suis'' might ameliorate the symptoms of chronic bowel disease. Large scale clinical trials (placebo-controlled cross-over studies) are currently in progress to test this hypothesis.

In experimental models, ''Trichuris'' markedly increases T-regulatory activity, thereby suppressing some immune-mediated diseases (Th2 responses increased; Th1 responses decreased). There is a theory that some human immune-mediated diseases are largely restricted to affluent developed countries (like inflammatory bowel disease and Crohn's disease) occur because the human immune system has evolved with T-regulating helminths constantly present, and therefore tends to go into overdrive in some individuals if this external regulatory influence is lacking. This had led to the hypothesis that strictly controlled exposure of selected human patients to ''T. suis'' might ameliorate the symptoms of chronic bowel disease. Large scale clinical trials (placebo-controlled cross-over studies) are currently in progress to test this hypothesis.

[[Category:Trichinelloidea]]

[[Category:Trichinelloidea]]