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Also known as: '''''Exudative Cholangitis — Cholangiohepatitis —Suppurative Cholangitis'''''

Also known as: '''''Exudative Cholangitis — Cholangiohepatitis —Suppurative Cholangitis'''''

==Description==

==Introduction==

'''Neutrophilic cholangiohepatitis''' is characterised by infiltration of large numbers of [[Neutrophils|neutrophils]] into portal areas of the [[Liver - Anatomy & Physiology|liver]] and into the [[Liver - Anatomy & Physiology #Hepatic Duct Systems|bile ducts]].  It results from ascending bacterial infection from the [[Small Intestine Overview - Anatomy & Physiology|small intestines]].  ''[[Escherichia coli]]'', [[:Category:Staphylococcus species|''Staphylococcus spp.'']], ''[[:Category:Streptococcus species|Streptococcus]] spp.'', ''[[:Category:Clostridium species|Clostridium spp.]]'', ''[[Bacillus species|Bacillus spp.]]'', ''[[:Category:Actinomyces|Actinomyces spp.]]'', ''Bacteroides spp'' and occasionally ''[[Salmonella|Salmonella spp.]]'' have been isolated.  Concurrent biliary tract disease are common in cats, especially [[Pancreatitis - Dog and Cat|pancreatitis]] and [[Inflammatory Bowel Disease|inflammatory bowel disease]].  Other predisposing factors include congenital or acquired abnormalities of the biliary system such as that of anatomic abnormalities of the [[Gall Bladder - Anatomy & Physiology|gall bladder]] or common bile duct, bile duct obstruction caused by inspissated bile, cholelithiasis and cholecystitis.

'''Neutrophilic cholangiohepatitis''' is characterised by infiltration of large numbers of [[Neutrophils|neutrophils]] into portal areas of the [[Liver - Anatomy & Physiology|liver]] and into the [[Liver - Anatomy & Physiology #Hepatic Duct Systems|bile ducts]].  It results from ascending bacterial infection from the [[Small Intestine Overview - Anatomy & Physiology|small intestines]].  ''[[Escherichia coli]]'', [[:Category:Staphylococcus species|''Staphylococcus spp.'']], ''[[:Category:Streptococcus species|Streptococcus]] spp.'', ''[[:Category:Clostridium species|Clostridium spp.]]'', ''[[Bacillus species|Bacillus spp.]]'', ''[[:Category:Actinomyces|Actinomyces spp.]]'', ''Bacteroides spp'' and occasionally ''[[Salmonella|Salmonella spp.]]'' have been isolated.  Concurrent biliary tract disease are common in cats, especially [[Pancreatitis|pancreatitis]] and [[Inflammatory Bowel Disease|inflammatory bowel disease]].  Other predisposing factors include congenital or acquired abnormalities of the biliary system such as that of anatomic abnormalities of the [[Gall Bladder - Anatomy & Physiology|gall bladder]] or common bile duct, bile duct obstruction caused by inspissated bile, cholelithiasis and cholecystitis.

==Signalment==

==Signalment==

==Diagnosis==

==Diagnosis==

===History and Clinical Signs===

===History and Clinical Signs===

Acute presentation with severe illness in contrast to cats with [[Cholangitis, Lymphocytic|Lymphocytic cholangitis]] who often do not appear ill. Signs include pyrexia, depression, lethargy, abdominal pain, [[Icterus|jaundice]] and dehydration.

Acute presentation with severe illness in contrast to cats with [[Cholangitis, Lymphocytic|Lymphocytic cholangitis]] who often do not appear ill. Signs include pyrexia, depression, lethargy, abdominal pain, [[Icterus|jaundice]], dehydration ,anorexia and vomiting. If presented whilst the disease is chronic, signs will include episodic anorexia, vomiting, jaundice, weight loss and possibly hepatomegaly or ascites. Many cases will have concurrent [[IBD]].

===Laboratory Tests===

===Laboratory Tests===

Good prognosis provided the cats are treated early and appropriately.

Good prognosis provided the cats are treated early and appropriately.

[[File:CABI logo.jpg|left|90px]]

|literature search = [http://www.cabdirect.org/search.html?q=title%3A%28Cholangitis%29+AND+title%3A%28Neutrophilic%29 Neutrophilic Cholangitis publications]

 

 

[http://www.cabdirect.org/search.html?q=title%3A%28Cholangitis%29+AND+title%3A%28Neutrophilic%29 Neutrophilic Cholangitis publications]

==References==

==References==

*Marks, S.L. (2003). '''Update on the Diagnosis and Management of Feline Cholangiohepatitis''' ''Waltham Feline Medicine Symposium''.

*Marks, S.L. (2003). '''Update on the Diagnosis and Management of Feline Cholangiohepatitis''' ''Waltham Feline Medicine Symposium''.

[[Category:Gall_Bladder_and_Tract_-_Pathology]]]]

 

 

 

[[Category:Gall_Bladder_and_Tract_-_Pathology]]

[[Category:Expert Review]]

[[Category:Expert Review]]