Changes

Disease may be truly idiopathic (dogs and cats) or may be secondary to another disease process, often chronic inflammation or neoplasia.  Chronic antigenic stimulation induces the overproduction of AA protein which may become deposited throughout the body.   

Disease may be truly idiopathic (dogs and cats) or may be secondary to another disease process, often chronic inflammation or neoplasia.  Chronic antigenic stimulation induces the overproduction of AA protein which may become deposited throughout the body.   

Deposits are found:

Deposits are found in:

*Renal vessels and glomeruli.

*Renal vessels and glomeruli.

*Splenic white pulp.

*Splenic white pulp.

*Space if Disse.

*Space of Disse.

*Coronary arteries.

*Coronary arteries.

*Meningeal arteries.

*Meningeal arteries.