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Ethylene Glycol Toxicity (view source)
Revision as of 21:53, 21 November 2010
, 21:53, 21 November 2010→Laboratory Tests
===Laboratory Tests===
===Laboratory Tests===
*'''Blood:'''Metabolic Acidosis, increased serum osmolality, increased anion gap, decreased plasma bicarbonate concentration, decreased PCO2, decreased, blood pH, ethylene glycol (in-house colorimetric kit) <ref name="multiples"> '''BSAVA Canine and Feline Emergency Care''', Second Edition (2007), Chapter 19, p286-7 </ref>, although concurrent use of drugs such as diazepam and etomidate both of which contain propylene glycol can confound results <ref name="multiples"> '''Testbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1975 <ref/>.
*'''Blood:'''Metabolic Acidosis, increased serum osmolality, increased anion gap, decreased plasma bicarbonate concentration, decreased PCO2, decreased, blood pH, ethylene glycol (in-house colorimetric kit) <ref name="multiples"> '''BSAVA Canine and Feline Emergency Care''', Second Edition (2007), Chapter 19, p286-7 </ref>, although concurrent use of drugs such as diazepam and etomidate both of which contain propylene glycol can confound results <ref name="multiples"> '''Testbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1975 <ref/>. Hyperphosphataemia can be present in later stages due to acute renal failure <ref name="multiples"> '''Textbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1747 </ref>, and hypocalcaemia as a consequence of this<ref name="multiples"> '''Textbook of Veterinary Internal Medicine''', (Seventh Edition), ''Ettinger and Feldman''; p1747 </ref> and also as a consequence of ionised calcium binding to ethylene glycol metabolites.
*'''Urine:'''increased urea and creatinine, hyperkalaemia, calcium oxalate crystalluria <ref name="multiples"> '''BSAVA Canine and Feline Emergency Care''', Second Edition 2007, Chapter 19, p286-7 </ref>, ethylene glycol (in-house colorimteric kit)<ref name="multiples"> '''BSAVA Canine and Feline Emergency Care''', Second Edition 2007, Chapter 19, p286-7 </ref>.
*'''Urine:'''increased urea and creatinine, hyperkalaemia, calcium oxalate crystalluria <ref name="multiples"> '''BSAVA Canine and Feline Emergency Care''', Second Edition 2007, Chapter 19, p286-7 </ref>, ethylene glycol (in-house colorimteric kit)<ref name="multiples"> '''BSAVA Canine and Feline Emergency Care''', Second Edition 2007, Chapter 19, p286-7 </ref>.