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Complement Associated Diseases (view source)
Revision as of 10:37, 6 September 2007
, 10:37, 6 September 2007→Membrane Attack Complex
* This is the lytic pathway of complement function.
* This is the lytic pathway of complement function.
* Can be initiated via either C3bB¯b3b or C4b2¯b3b.
* Can be initiated via either C3bB¯b3b or C4b2¯b3b.
C5b, like C3b is also very short-lived and biological active. It rapidly attaches to cell surfaces and binds to one C6 (see Figure 2). The C5bC6 complex binds one C7 and then one C8 molecule in turn. Finally about 16 C9 molecules bind and polymerize within the cell membrane. This polymerization of C9 results in a small pore being formed, which causes cell lysis by osmotic shock.
** Split C5 to:
*** C5a - pro-inflammatory.
*** C5b - the first molecule of the MAC.
* C5b is very short-lived and biologically active.
** Rapidly attaches to cell surfaces and binds to one C6 molecule.
* The C5bC6 complex binds one C7 and then one C8 molecule in turn.
* Finally, about 16 C9 molecules bind and polymerize within the cell membrane.
** This polymerization of C9 results in a small pore being formed.
*** Causes cell lysis by osmotic shock.
==BIOLOGICAL ACTIVITIES OF COMPLEMENT COMPONENTS==
==BIOLOGICAL ACTIVITIES OF COMPLEMENT COMPONENTS==