Ichthyosis

• Inherited cutaneous disease
• Occurs in dogs and cattle
• Grossly:
  • Thickened skin due to hyperkeratosis
  • May crack resembling fish scales
• Increased adherence of keratocytes preventing normal desquamation
• In cattle occurs in two forms:
  • Ichthiosis fetalis - fatal, stillborn calves or die within days of birth
  • Ichthiosis congenita - folded and thickened skin, fissures and partial alopecia