Osteopetrosis
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(Marble bone disease)
- Occurs in sheep, dogs, cattle, horses
- Failure of resorption by osteoclasts -> failure of remodelling of cancellous bone
- Bones become thickened and dense but brittle
- Marrow cavites are full of unresorbed primary spongiosa
- Thickened intramembranous bones of skull -> altered shape of brain
- Associated with severe viral infections, e.g. FeLV, BVD
- Hereditary in Angus cattle