Water Excess

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Water Excess

  • Known as "water intoxication".

Causes

  • Results from induced hypo-osmolality, e.g.
    • Excessive administration of water to previously deprived animals.
    • Administration of large volumes of water to animals with acute renal failure.

Effects

  • The ECF osmolality is reduced.
  • Water is transferred to the cells and they become "water-logged".
    • Intracellular oedema in the CNS results in convulsions and death.