Testicular Feminisation
Revision as of 10:52, 3 July 2008 by Lwilkie (talk | contribs) (New page: '''''Aetiology''''' * Genotype XY as should be in the male. * Testes develop normally and secrete Androgens and MIH * Foetal genetalia are genetically insensitive to the actions of Androg...)
Aetiology
- Genotype XY as should be in the male.
- Testes develop normally and secrete Androgens and MIH
- Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
Consequence
- Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
- Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
- Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.