Bovine Papillomaviruses

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  • 2 groups:
  1. Fibropapillomas: viral DNA sequences, but no virus found
  2. Epithelial Papillomas: virus found
  • Calves most commonly affected
  • Usually resolves spontaneously
  • Can undergo malignant transformation to alimentary carcinomas
    • Usually concurrent with grazing bracken (co-carcinogen) and ingesting quercetin (immunosuppressant)
  • Can cause squamous cell carcinoma of the eye in Hereford cattle, where UV light acts as the co-carcinogen
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