Canine Cyclic Haematopoiesis

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Appearance of a puppy with Grey Collie syndrome - Copyright Michelle Tennis & Peggy Melton
  • Also called Grey Collie Syndrome
  • Autosomal recessive
  • Insertion mutation in AP3B1 gene
  • Diluted grey coat colour, stunted growth, poor wound healing
  • Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from bone marrow
  • Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract
    • E.g. pyrexia, diarrhoea, gingivitis and arthritis
  • Puppies can be distinguished from other litter mates by the diluted grey colouring
  • Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age
  • Affected animals rarely live beyond 2-3 years with most puppies dying within a few weeks of birth

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