Myasthenia Gravis
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Description
Myasthenia gravis is a disease of the neuromuscular junction that occurs due to a defect or absence of nicotinic acetylcholine receptors on the post-synaptic membrane (in the congenital form) or due to the presence of antibodies that bind to the receptors and prevent them from functioning normally (in the acquired form). The classical focal form of myasthenia gravis affects only the extraocular muscles, the cranial oesophagus and the muscles innervated by cranial nerves V, VII and IX. 80% of animals diagnosed with myasthenia gravis have megaoesophagus at presentation.
Signalment
Diagnosis
Clinical Signs
Treatment
Prognosis
References
- Animals develop antibodies to nicotinic acetylcholine receptors.
- Results in generalised muscle weakness and or megaoesophagus.
Pathogenesis: Type II hypersensitivity