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Adrenal Glands - Anatomy & Physiology (view source)
Revision as of 15:16, 11 September 2008
, 15:16, 11 September 2008→Adrenal Cortex
2) Hydroxylation reactions occur in the mitochondria and endoplasmic reticulum converting pregnenolone into specific hormones. The location within the cortex determines the hormones produced.
2) Hydroxylation reactions occur in the mitochondria and endoplasmic reticulum converting pregnenolone into specific hormones. The location within the cortex determines the hormones produced.
'''Mineralocorticoids'''
===='''Mineralocorticoids'''====
These hormones regulate the mtabolism of inorganic ions, such sodium, potassium and chloride. Several hormones are produced but the most important is '''aldosterone'''.
These hormones regulate the mtabolism of inorganic ions, such sodium, potassium and chloride. Several hormones are produced but the most important is '''aldosterone'''.
It is formed in the zona glomerulosa by the conversion of pregnenolone to cortisol and then to corticosterone before finally becoming aldosterone. It circulates by binding to albumin and cortisol-binding globulin. It's plasma half-life is 20 minutes. It is eventually inactivated in the liver, where it binds to glucuronic acid and is excreted in bile and urine.
It is formed in the zona glomerulosa by the conversion of pregnenolone to cortisol and then to corticosterone before finally becoming aldosterone. It circulates by binding to albumin and cortisol-binding globulin. It's plasma half-life is 20 minutes. It is eventually inactivated in the liver, where it binds to glucuronic acid and is excreted in bile and urine.
''Regulation and action'' - It's main regulators of synthesis and secretion are; '''Renin''' and extracellular concentrations of potassium ions. Its main action is upon renal regulation and electrolyte and fluid balance. These are fully explained within the '''[[Important Hormonal Regulators of the Kidney - Anatomy & Physiology|renin-angiotensin and aldosterone]] page.
'''Regulation and action''' - It's main regulators of synthesis and secretion are; '''Renin''' and extracellular concentrations of potassium ions. Its main action is upon renal regulation and electrolyte and fluid balance. These are fully explained within the '''[[Important Hormonal Regulators of the Kidney - Anatomy & Physiology|renin-angiotensin and aldosterone]] page.
==Histology of the Adrenal Glands==
==Histology of the Adrenal Glands==