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==Actions==
==Actions==
Alpha-2 agonists have a wide range of actions, due to the presence of alpha-2 receptors throughout the body. The actions most useful pharmacologically are '''sedation''', '''anxiolysis''' and '''analgesia'''. The drugs also have a huge '''anaesthetic sparing effect''', reducing MAC by 50-95%. They also give '''muscle relaxation'''.
Alpha-2 agonists have a wide range of actions, due to the presence of alpha-2 receptors throughout the body. The most useful pharmacological actions are '''sedation''', '''anxiolysis''' and '''analgesia'''. The drugs also have a huge '''anaesthetic sparing effect''', reducing MAC by 50-95%. They also give '''muscle relaxation'''.
Other systems affected by alpha-2 agonists include:
Other systems affected by alpha-2 agonists include:
* <u>Respiratory System</u>
* <u>Respiratory System</u>
** The drugs cause mild depression of the respiratory system.
** The drugs cause mild depression of the respiratory system.
** The response to hypercapnoea is reduced.
** The response to hypercapnia is reduced.
* <u>Gastrointestinal Tract</u>
* <u>Gastrointestinal Tract</u>
** Alpha-2 agonists cause extreme vomiting in dogs and cats. [[#Xylazine|Xylazine]] is the worst culprit for this.
** Alpha-2 agonists cause extreme vomiting in dogs and cats. [[#Xylazine|Xylazine]] is the worst culprit for this.
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[http://www.cabi.org/cabdirect/FullTextPDF/2005/20053164006.pdf ''' Medetomidine: a review.''' Read, M.; Ontario Veterinary Medical Association, Milton, Canada, Better medicine, better life. OVMA Conference Proceedings 2005, 2005, pp 31-34 - '''Full text Article''']
[http://www.cabi.org/cabdirect/FullTextPDF/2005/20053164006.pdf ''' Medetomidine: a review.''' Read, M.; Ontario Veterinary Medical Association, Milton, Canada, Better medicine, better life. OVMA Conference Proceedings 2005, 2005, pp 31-34 - '''Full text Article''']
|Vetstream = [https://www.vetstream.com/canis/Content/Generic/gen00160.asp Medetomidine]
[[Category:Sedatives and Tranquilisers]]
[[Category:Sedatives and Tranquilisers]]
[[Category:Injectable Anaesthetic Agents]]
[[Category:Injectable Anaesthetic Agents]]