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** Pre-synaptic inhibition of noradrenaline release gives a reduced sympathetic outflow. This decreases heart rate and offsets vasoconstriction.  
 
** Pre-synaptic inhibition of noradrenaline release gives a reduced sympathetic outflow. This decreases heart rate and offsets vasoconstriction.  
 
* <u>Respiratory System</u>
 
* <u>Respiratory System</u>
** The drugs cause mild depression of the respiratory systsem.
+
** The drugs cause mild depression of the respiratory system.
 
** The response to hypercapnoea is reduced.
 
** The response to hypercapnoea is reduced.
 
* <u>Gastrointestinal Tract</u>
 
* <u>Gastrointestinal Tract</u>
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