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==Introdcution==
==Introduction==
Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli,
Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli,
[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords).
[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords).
Affected organs are non-functional and appear waxy and pale.
Affected organs are non-functional and appear waxy and pale.
*Amyloid is an insoluble protein that can accumulate in the kidney and compress the glomerulus, interfering with its normal function.
*Hypoproteinaemia and nephrotic syndrome can result due to substantial protein loss in the urine.
*Causes can be idiopathic or associated with underlying chronic inflammatory conditions.
'''Gross pathology'''
*Kidneys are firm, enlarged, and pale. Affected glomeruli may be seen as yellowish spots in the cortex.
*Amyloid can be visualised by treating the freshly cut surface of the kidneys with iodine.
'''Histopathology'''
*Amyloid stains pink with congo red.
*Presence of a pink, homogenous material replacing the epithelium and endothelium of the glomerulus.
<center><gallery>
Image:Congo red.jpg|'''Amyloidosis Stained with Congo Red''' <br> Susan Rhind, University of Edinburgh
Image:Amyloidosis_histology.jpg|'''Amyloidosis Histology''' <br> Susan Rhind University of Edinburgh
</gallery></center>
==Test yourself with the Vascular Pathology Flashcards==
==Test yourself with the Vascular Pathology Flashcards==
[[Vascular Pathology Flashcards]]
[[Vascular Pathology Flashcards]]
[[Category:Liver_-_Storage_Diseases]]
[[Category:Liver_-_Storage_Diseases]]
[[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]]
[[Category:Cardiovascular_System_-_Degenerative_Pathology]][[Category:Cardiovascular_System_-_Vascular_Pathology]][[Category:Arterial_Pathology]]
[[Category:Glomerular Disease]]
[[Category:To Do - Urinary]]