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→Clinical Significance
The competence of the enterohepatic circulation is usually assessed by performing a bile acid stimulation test, where an animal fasted for 12 hours is then fed a test meal and the serum bile acid concentration is measured before and two hors after the meal. The post-prandial measurement may be '''elevated''' in the following conditions:
The competence of the enterohepatic circulation is usually assessed by performing a bile acid stimulation test, where an animal fasted for 12 hours is then fed a test meal and the serum bile acid concentration is measured before and two hors after the meal. The post-prandial measurement may be '''elevated''' in the following conditions:
*'''Hepatobiliary disease''', but the type of disease cannot be determined from this finding alone.
*'''Hepatobiliary disease''', but the type of disease cannot be determined from this finding alone.
*'''Cholestasis''', including the mild cholestasis that occurs due to hepatic hydropic change in [[Hyperadrenocorticism|hyperadrenocorticism]] in dogs and [[Biliary Tract - Obstruction|extra-hepatic biliary obstruction]].
*'''Cholestasis''', including the mild cholestasis that occurs due to hepatic hydropic change in [[Canine Hyperadrenocorticism - Cushing's Disease|hyperadrenocorticism]] in dogs and [[Biliary Tract - Obstruction|extra-hepatic biliary obstruction]].
*[[Portosystemic Shunt|'''Portosystemic shunts''']] or [[Hepatic Microvascular Dysplasia|'''microvascular dysplasia''']], in which the portal blood is directed into the systemic circulation, disrupting the enterohepatic circulation.
*[[Portosystemic Shunt|'''Portosystemic shunts''']] or [[Hepatic Microvascular Dysplasia|'''microvascular dysplasia''']], in which the portal blood is directed into the systemic circulation, disrupting the enterohepatic circulation.
*[[Small Intestinal Bacterial Overgrowth and Antibiotic Responsive Diarrhoea|Small intestinal bacterial overgrowth]] due to deconjugation of bile acids by intestinal bacteria.
*[[Small Intestinal Bacterial Overgrowth and Antibiotic Responsive Diarrhoea|'''Small intestinal bacterial overgrowth''']] due to deconjugation of bile acids by intestinal bacteria.
*Increased post-prandial bile acid concentration may be a normal findings in '''Maltese terriers'''.
*Increased post-prandial bile acid concentration may be a normal findings in '''Maltese terriers'''.