Changes

Jump to navigation Jump to search

Bones - Anatomy & Physiology (view source)

Revision as of 23:00, 8 December 2015

1,331 bytes removed ,  23:00, 8 December 2015
m
→‎Types of Bone
Line 1: Line 1:  +
{{OpenPagesTop}}
 
==Overview==
 
==Overview==
 +
[[Image:Horse Skeleton.jpg|thumb|right|250px|Horse Skeleton - Copyright Nottingham]]
 +
[[Image:Growth plate.jpg|right|thumb|250px|<small><center>Growth plate (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
 +
[[Image:Growth plate closer.jpg|right|thumb|250px|<small><center>Growth plate magnified (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
 +
[[Image:Aspinall Slide1.JPG|thumb|right|250px|<small>Image from [http://www.elsevierhealth.co.uk/veterinary-nursing/spe-60136/ Aspinall, The Complete Textbook of Veterinary Nursing], Elsevier Health Sciences, ''All rights reserved''</small>]]
 +
Bone comprises the structure of the skeletal system and provides lever arms for locomotion. Bone also plays important roles in maintaining mineral homeostasis, as well as providing the environment for [[Haematopoiesis - Overview|hematopoesis]] in [[Bone Marrow|marrow]].
 +
 +
'''Short bones''' - Endochondral ossification continues in the diaphysis, until only the cartilage rim remains.
 +
 +
'''Long bones''' - A secondary center of ossification develops in the epiphyses.
 +
 +
See [[Bone & Cartilage Development - Anatomy & Physiology|Bone and Cartilage Development]]
   −
Bone comprises the structure of the skeletal system and provides lever arms for locomotion. Bone also plays important roles in maintaining mineral homeostasis, as well as providing the environment for hematopoesis in marrow.
  −
[[Image:Horse Skeleton.jpg|thumb|right|250px|Horse Skeleton - Copyright Nottingham]]
      
==Bone Growth==
 
==Bone Growth==
    
===Length===
 
===Length===
−
The '''epiphyseal growth plate (EGP)''' allows the [[Bones and Cartilage - Anatomy & Physiology#Types of Bone|bone]] to continue to grow in length after birth. The EPG is a region of continuous chondroblast differentiation and maturation and can be divided into five zones:
+
The '''epiphyseal growth plate (EGP, physis)''' is a transverse disc of cartilage between the two ossification centers and allows the bone to continue to grow in length after birth. It then closes. The EGP is a region of continuous chondroblast differentiation and maturation and can be divided into five zones:
    
# '''Germinal Zone''' - chondroblast division at a low rate, and self renewal.
 
# '''Germinal Zone''' - chondroblast division at a low rate, and self renewal.
Line 20: Line 30:       −
[[Image:Growth plate.jpg|right|thumb|250px|<small><center>Growth plate (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
+
==Bone Remodeling==
−
 
+
[[Image:Haversian system.jpg|right|thumb|250px|<small><center>Haversian system (Courtesy of RVC Histology images)</center></small>]]
−
==Bone Growth and Remodeling==
+
'''Primary''' bone has not yet been '''remodelled'''. It contains less mineral and more randomly arranged collagen fibers, known as trabecular organization. Remodelling of bone occurs by '''haversian canals'''. The osteoclasts dig out the canal longitudinally through the bone connecting with bone marrow cavity and periosteum. They are followed by anastamosing and branching blood vessels. Concentric bony lamellae are laid down with rows of interconnected lacunae containing '''osteocytes''' within. The osteocytes communicate by channels in young bones. Phased resorption happens concurrently.
−
 
  −
'''Short bones'''- Endochondral ossification continues in the diaphysis, until only the cartilage rim remains.
     −
'''Long bones'''- A secondary center of ossification develops in the epiphyses.
+
'''Haversion canals + lamellae + osteocytes = Haversion system'''
−
 
  −
'''Epiphyseal Growth Plate'''
  −
 
  −
The growth plate is a transverse disc of cartilate between the two ossification centers, and allows longitudinal growth to continue to maturity. It then closes. The cartilage of the epiphyseal growth plate is divided into: (from right to left on the magnified image)
  −
 
  −
1. Resting (reserve) zone
  −
2. Proliferative zone
  −
3. Hypertrophic zone
  −
 
  −
'''Primary''' bone has not yet been '''remodelled'''. It contains less mineral and more randomly arranged collagen fibers, known as trabecular organization. Remodelling of bone occurs by '''haversian canals'''. The osteoclasts dig out the canal, followed by blood vessel invasion. Concentric lamellae are laid down and phased resorption happens concurrently.
      
==Types of Bone==
 
==Types of Bone==
Line 52: Line 50:  
Found in the skull, pelvic girdle, and scapula. It expands in two directions, with a broad surface for attachment of large muscle masses and protection of underlying structures.
 
Found in the skull, pelvic girdle, and scapula. It expands in two directions, with a broad surface for attachment of large muscle masses and protection of underlying structures.
   −
4. '''Sesamoid Bones'''
+
4. '''Irregular Bone'''
 +
 
 +
Found in the vertebrae.
 +
 
 +
5. '''Sesamoid Bone'''
    
Eg. Patella and navicular bone. Found within tendons, where they change direction over prominences that would otherwise cause damage. They form '''synovial joints''' with major bones with which they are in contact. They also serve to displace tendon from the axis of the joint, increasing the leverage exerted by the muscle.
 
Eg. Patella and navicular bone. Found within tendons, where they change direction over prominences that would otherwise cause damage. They form '''synovial joints''' with major bones with which they are in contact. They also serve to displace tendon from the axis of the joint, increasing the leverage exerted by the muscle.
   −
5. '''Splanchnic Bones'''
+
6. '''Splanchnic Bone'''
    
Develop in soft organs remote from skeletal connection, eg. '''os penis'''.  
 
Develop in soft organs remote from skeletal connection, eg. '''os penis'''.  
   −
6. '''Pneumatic Bones'''
+
7. '''Pneumatic Bone'''
    
Excavated to contain air spaces, such as the skull in the instance of paranasal sinuses, and the post-cranial skeleton of birds.
 
Excavated to contain air spaces, such as the skull in the instance of paranasal sinuses, and the post-cranial skeleton of birds.
    
==Composition of Bone==
 
==Composition of Bone==
−
   
[[Image:Bone histo.jpg|right|thumb|250px|<small><center>Histological structure of bone (Courtesy of RVC Histology images)</center></small>]]
 
[[Image:Bone histo.jpg|right|thumb|250px|<small><center>Histological structure of bone (Courtesy of RVC Histology images)</center></small>]]
 
[[Image:Bone micro structure.jpg|right|thumb|250px|<small><center>Microscopic bone (Courtesy of RVC Histology images)</center></small>]]
 
[[Image:Bone micro structure.jpg|right|thumb|250px|<small><center>Microscopic bone (Courtesy of RVC Histology images)</center></small>]]
−
   
Bone is a hard, highly specialised connective tissue . It consists of interconnected cells embedded in a calcified, collagenous matrix. It is a living, dynamic, responsive tissue, growing and remodelling throughout life.
 
Bone is a hard, highly specialised connective tissue . It consists of interconnected cells embedded in a calcified, collagenous matrix. It is a living, dynamic, responsive tissue, growing and remodelling throughout life.
   −
Bone is comprised of:
+
Bone is composed of:
    
===Matrix===
 
===Matrix===
   −
'''Osteoid'''- An organic, uncalcified, homogeneous substance that stains light pink with H&E . Osteoid consists of type I collagen (90%), which resists tension and bone-specific proteins(10%), including; Osteonectin, Osteopontin and Osteocalcin.
+
'''Osteoid'''- An organic, uncalcified, homogeneous substance that stains light pink with H&E . Osteoid consists of type I collagen (90%), which resists tension, and bone-specific proteins (10%), including; Osteonectin, Osteopontin and Osteocalcin.
   −
'''Mineral'''- An inorganic component, provides rigidity. Consists of a crystalline lattice of calcium phosphate and calcium carbonate. It also contains Mg, Mn, Zn, Cu, Na, F. It accounts for 65% of bone.
+
'''Mineral'''- An inorganic component that provides rigidity and consists of a crystalline lattice of calcium phosphate and calcium carbonate. It also contains Mg, Mn, Zn, Cu, Na, F. It accounts for 65% of bone.
    
===Cells===
 
===Cells===
Line 83: Line 83:  
'''Osteoblasts'''
 
'''Osteoblasts'''
   −
A single layer of mesenchymal cells which synthesize bone extracellular matrix (osteoid). When active, thet appear plump and cuboidal, with a basophilic cytoplasm. The cell membranes are rich in alkaline phosphatase (ALP). The cells are possibly involved in pumping calcium across membranes. They are promoted by growth factors and have receptors for [[Bones - normal#Bone resorption|PTH]]. They contract in response, which provides space for osteoclasts to attach. When they are inactive, there is less cytoplasm, so they become flattened.
+
A single layer of mesenchymal cells which synthesize bone extracellular matrix (osteoid). When active, they appear plump and cuboidal, with a basophilic cytoplasm. The cell membranes are rich in alkaline phosphatase (ALP). The cells are possibly involved in pumping calcium across membranes. They are promoted by growth factors and have receptors for [[Calcium#Parathyroid Hormone (PTH)|PTH]]. They contract in response, which provides space for osteoclasts to attach. When they are inactive, there is less cytoplasm, so they become flattened.
    
'''Osteocytes'''
 
'''Osteocytes'''
   −
osteoblasts are embedded in their own matrix; reside within '''lacunae''' and are interconnected via channels forming '''canaliculi'''. Canaliculi create connections to form a huge neural-like junctional organization. They contact osteoblasts and each other with cytoplasmic processes and reach through canaliculi in the mineralised bone matrix. Osteocytes regulate the composition of bone fluid.
+
Osteocytes are embedded in their own matrix; reside within '''lacunae''' and are interconnected via channels forming '''canaliculi'''. Canaliculi create connections to form a huge neural-like junctional organization. They contact osteoblasts and each other with cytoplasmic processes and reach through canaliculi in the mineralised bone matrix. Osteocytes regulate the composition of bone fluid.
    
'''Osteoclasts'''
 
'''Osteoclasts'''
   −
Osteoclasts are giant (multinucleate [[Monocytes|monocytes]]) cells. Histologically, they are large, often multinucleated cells. They have an acidophilic cytoplasm. They sit in the bone surface depression known as, '''howship's lacuna'''. Osteoclasts respond to vitamin D by increasing their numbers and activity (parathyroid independent). Osteoclasts act to resorb the bone ECM. They firstly dissolve mineral followed by collagen, using the brush border. They do <u>not</u> have receptors for PTH, but do have receptors for [[Calcium#Calcitonin|calcitonin]].  
+
Osteoclasts are giant (multinucleate [[Monocytes|monocytes]]) cells. Histologically, they are large, often multinucleated cells. They have an acidophilic cytoplasm. They sit in the bone surface depression known as, '''howship's lacuna'''. Osteoclasts respond to [[Calcium#Calcitriol (Activated Vitamin D3)|vitamin D]] by increasing their numbers and activity (parathyroid independent). Osteoclasts act to resorb the bone extracellular matrix (ECM). They firstly dissolve mineral followed by collagen, using the brush border. They do <u>not</u> have receptors for PTH, but do have receptors for [[Calcium#Calcitonin|calcitonin]].  
    
Osteoblasts, osteocytes, chondroblasts and chondrocytes are derived from the stromal fibroblastic system ('''osteoprogenitor cells'''). Osteoclasts are derived from the haematopoietic system.
 
Osteoblasts, osteocytes, chondroblasts and chondrocytes are derived from the stromal fibroblastic system ('''osteoprogenitor cells'''). Osteoclasts are derived from the haematopoietic system.
   −
==Organization of Bone==
+
==Organisation of Bone==
   −
The normal progression of bone is from woven bone to lamellar bone, even in pathology, except for [[Bones Hyperplastic and Neoplastic - Pathology#Craniomandibular osteopathy|canine craniomandibular osteopathy]] and [[Bones Metabolic - Pathology#Hypervitaminosis D|hypervitaminosis D]], where lamellar bone is replaced by woven bone.
+
The normal progression of bone is from woven bone to lamellar bone, even in pathology, except for [[Craniomandibular Osteopathy|canine craniomandibular osteopathy]] and [[Hypervitaminosis D|hypervitaminosis D]], where lamellar bone is replaced by woven bone.
    
===Woven bone===
 
===Woven bone===
Line 109: Line 109:  
1. '''Compact bone (cortical)'''  
 
1. '''Compact bone (cortical)'''  
   −
A sheath covers the external surface of long bone. It is thicker in the shaft and thins over the epiphyses. It is comprised of thin lamallae in a series of concentric tubes arranged around small central canals (collectively known as an '''osteone'''). It forms 80% of the total bone mass and consists of cells and interstitial substance - 30% ossein (type of collagen) and 70% minerals, especially calcium phosphate.  
+
A sheath covers the external surface of long bone. It is thicker in the shaft and thins over the epiphyses. It is composed of thin lamallae in a series of concentric tubes arranged around small central canals (collectively known as an '''osteone'''). It forms 80% of the total bone mass and consists of cells and interstitial substance - 30% ossein (type of collagen) and 70% minerals, especially calcium phosphate.  
    
2. '''Cancellous bone (spongy or trabecular)'''  
 
2. '''Cancellous bone (spongy or trabecular)'''  
Line 117: Line 117:  
===Laminar bone===
 
===Laminar bone===
   −
Formed on the periosteal surface of diaphysis. It accomodates rapid growth of large dogs and farm animals. Plates of woven bone from within the periosteum. As it forms, it fuses with the bone surface.
+
Formed on the periosteal surface of diaphysis. It accommodates rapid growth of large dogs and farm animals. Plates of woven bone from within the periosteum. As it forms, it fuses with the bone surface.
    
==Periosteum and blood supply==
 
==Periosteum and blood supply==
Line 123: Line 123:  
===Periosteum===
 
===Periosteum===
   −
The periosteum is the specialised sheath of connective tissue covering bone, except at the articular surfaces. It is loosely attached, except at tendon insertions and boney prominences. Histologically, there is an outer layer which is fibrous for support, and an inner layer that is osteogenic. It consists of a rich supply of nerves and lymph vessels, including nutrient, metaphyseal and periosteal arteries. The normal flow of blood from the medulla to the periosteum is due to higher pressures in the medulla. Young animals have a greater blood supply.  
+
The periosteum is the specialised sheath of connective tissue covering bone, except at the articular surfaces. It is loosely attached, except at tendon insertions and bony prominences. Histologically, there is an outer layer which is fibrous for support, and an inner layer that is osteogenic. It consists of a rich supply of nerves and lymph vessels, including nutrient, metaphyseal and periosteal arteries. The normal flow of blood from the medulla to the periosteum is due to higher pressures in the medulla. Young animals have a greater blood supply.  
    
The '''endosteum''' lines the marrow cavity. The '''medullary cavity and cancellous interstitium''' is for bone marrow storage and production. [[Bone Marrow - Anatomy & Physiology#Red marrow|'''Red marrow''']] is a richly vascularized, gelatinous tissue with hematopoeitic properties found abundantly in young animals and [[Bone Marrow - Anatomy & Physiology#Yellow marrow|'''yellow marrow''']] has been converted from red marrow by fat infiltration, causing hematopoeitic properties to dwindle.
 
The '''endosteum''' lines the marrow cavity. The '''medullary cavity and cancellous interstitium''' is for bone marrow storage and production. [[Bone Marrow - Anatomy & Physiology#Red marrow|'''Red marrow''']] is a richly vascularized, gelatinous tissue with hematopoeitic properties found abundantly in young animals and [[Bone Marrow - Anatomy & Physiology#Yellow marrow|'''yellow marrow''']] has been converted from red marrow by fat infiltration, causing hematopoeitic properties to dwindle.
Line 141: Line 141:  
'''Stress''': the internal forces resisting the change in dimension caused by the load.
 
'''Stress''': the internal forces resisting the change in dimension caused by the load.
   −
Cells use strain as a stimulus to adjust mass and architecture according to load. Resorption and osteogenesis happen concurrently to maintain bone integrity. This is mediated by two [[Parathyroid Glands - Pathology#Hormonal Control|hormones]]:
+
Cells use strain as a stimulus to adjust mass and architecture according to load. Resorption and osteogenesis happen concurrently to maintain bone integrity. This is mediated by two hormones:
   −
1. '''Parathyroid hormone (PTH)'''
+
1. [[Calcium#Parathyroid Hormone (PTH)|'''Parathyroid hormone (PTH)''']]
    
Produced by <u>chief cells in the parathyroid glands</u> in response to <u>decreased</u> serum calcium. In response, osteoclasts increase in number and resorb mineralised matrix to increase Ca in blood.
 
Produced by <u>chief cells in the parathyroid glands</u> in response to <u>decreased</u> serum calcium. In response, osteoclasts increase in number and resorb mineralised matrix to increase Ca in blood.
   −
2. '''Calcitonin'''
+
2. [[Calcium#Calcitonin|'''Calcitonin''']]
    
Produced by <u>C-cells in the thyroid glands</u> in response to <u>increased</u> serum calcium. Inhibits osteoclasts.
 
Produced by <u>C-cells in the thyroid glands</u> in response to <u>increased</u> serum calcium. Inhibits osteoclasts.
    
In neonates, bone growth predominates and modelling is important. In adults, the formation of bone is balanced by resorption - remodelling. It continues throughout life under the influence of hormones and mechanical pressure. Bone resorption may exceed formation in pathological states (hormonal, trauma, nutritional) or in old age and disuse.
 
In neonates, bone growth predominates and modelling is important. In adults, the formation of bone is balanced by resorption - remodelling. It continues throughout life under the influence of hormones and mechanical pressure. Bone resorption may exceed formation in pathological states (hormonal, trauma, nutritional) or in old age and disuse.
−
  −
==Structure and Function of Cartilage==
  −
  −
The function of cartilage is to resist compression, provide resilience and support at sites where flexibility is desired.
  −
  −
===Structure===
  −
  −
'''Chondrocytes'''
  −
  −
Reside within '''lacunae''' within ECM and are responsible for synthesizing the '''matrix'''. The matrix consists of type II collagen, (except fibrocartilage) and proteoglycans with associated glycosaminoglycans. They are continually turned over and are the most vulnerable component of cartilage. Decresed proteoglycan, causes loss of lubrication which results in collagen disruption. This includes, frays, clefts, fibrillation, ulcers, exposure of bone, [[Musculoskeletal Terminology - Pathology|eburnation, +/- osteophytes and joint mice]].
  −
  −
Cartilage is avascular, nutrients and waste move via diffusion. The perichondrium surrounding the cartilage is composed of two layers:
  −
  −
1. '''Fibrous'''- outer, dense irregular connective tissue.
  −
  −
2. '''Chondrogenic'''- inner, flattened cells that differentiate to chondrocytes.
  −
  −
==Types of Cartilage==
  −
  −
===Hyaline Cartilage===
  −
  −
The most abundant in the body. It is normally blue-white, smooth with a moist surface and turns yellow and becomes thinner in old age. It is found in nose, trachea, bronchi, ventral ends of ribs and sternal attachment. It is surrounded by perichondrium. It is at sites of articulation to provide a resilient, frictionless surface that resists compression. It is also found at epiphyseal growth plates.
  −
  −
===Elastic Cartilage===
  −
  −
Elastic cartilage has a yellow appearance and is found in auricular cartilage, larynx, eustacian tube, and epiglottis. It is surrounded by perichondrium and has resiliance with added flexibility.
  −
  −
===Fibrocartilage===
  −
  −
Fibrocartilage has more collagen ('''Type I''') and less proteglycans than hyaline. It resists high tensional strain and is often in transition with hyaline. It is found in intervertebral discs, tendon/ligament attachment to bone, joint menisci, and articular surface of some joints (such as the temperomandibular). It has NO perichondrium.
      
==Links==
 
==Links==
 +
Click here for information on [[Bone & Cartilage Development - Anatomy & Physiology|Bone and Cartilage Development]].
    
Click here for information on [[Bones - Pathology|bone and cartilage pathology]].
 
Click here for information on [[Bones - Pathology|bone and cartilage pathology]].
   −
Click here for information on [[Bone & Joint Development - Anatomy & Physiology]].
+
 
−
[[Category:Musculoskeletal System - Anatomy & Physiology]]
+
{{OpenPages}}
−
[[Category:To Do - AimeeHicks]][[Category:To Do - Review]]
+
[[Category:Bone and Cartilage - Anatomy & Physiology]]
 +
[[Category:A&P Done]]
Lshort5
1

edit

Retrieved from "https://en.wikivet.net/Special:MobileDiff/103709...183607"

Navigation menu