Changes

== Distribution ==

== Distribution ==

BHV-1 is distributed '''worldwide''' and has been diagnosed in all countries tested<ref name="Straub">Straub, O. C (1990) '''Infectious bovine rhinotracheitis virus'''. Virus infections of ruminants,71-108;10</ref>.

BHV-1 is distributed '''worldwide''' and has been diagnosed in all countries tested<ref name="Straub">Straub, O. C (1990) '''Infectious bovine rhinotracheitis virus'''. ''Virus infections of ruminants,'' 71-108;10</ref>.

In recent years, a few European countries have successfully eradicated the infection by applying a strict culling policy, e.g. Denmark, Sweden, Finland, Switzerland and Austria (OIE, 2005). Other countries have started similar control programmes.  

In recent years, a few European countries have successfully eradicated the infection by applying a strict culling policy, e.g. Denmark, Sweden, Finland, Switzerland and Austria. <ref name="OIE 2005">OIE (2005) '''Terrestrial Animal Health Code'''. Paris, France: ''Office International Des Epizooties'', Chapter 2.3.5.</ref> Other countries have started similar control programmes.  

The condition is '''endemic in the UK'''.

The condition is '''endemic in the UK'''.

== Signalment ==

== Signalment ==

The natural hosts are '''bovine species'''. BHV-1 has a narrow species specificity. The truly susceptible species can be defined as animals in which BHV-1 can establish a latent infection such as cattle and sheep<ref>Thiry, E et al., (2001). '''Risk evaluation of cross-infection of cattle with ruminant alphaherpesviruses related to bovine herpesvirus type 1.''' In: Körber R, ed. Tagungsbeiträge, 3. ''Internationales Symposium zur BHV-1- und BVD-Bekämpfung'', Stendal, in press</ref>, goats<ref> Six, A., Banks, M., Engels, M., Bascunana, C. R., Ackermann, M (2001) '''Latency and reactivation of bovine herpesvirus 1 (BHV-1) in goats and of caprine herpesvirus 1 (CapHV-1) in calves'''. Archives of Virology, 146(7):1325-1335; 38</ref> and other species belonging to the subfamily ''Bovidae''.

The natural hosts are '''bovine species'''. BHV-1 has a narrow species specificity. The truly susceptible species can be defined as animals in which BHV-1 can establish a latent infection such as cattle and sheep<ref>Thiry, E et al., (2001). '''Risk evaluation of cross-infection of cattle with ruminant alphaherpesviruses related to bovine herpesvirus type 1.''' In: Körber R, ed. Tagungsbeiträge, 3. ''Internationales Symposium zur BHV-1- und BVD-Bekämpfung'', Stendal, in press</ref>, goats<ref> Six, A., Banks, M., Engels, M., Bascunana, C. R., Ackermann, M (2001) '''Latency and reactivation of bovine herpesvirus 1 (BHV-1) in goats and of caprine herpesvirus 1 (CapHV-1) in calves'''. ''Archives of Virology'', 146(7):1325-1335; 38</ref> and other species belonging to the subfamily ''Bovidae''.

Outbreaks are most often seen in cattle between '''6 and 18 months''' of age though all ages of cattle are susceptible. Calves are usually protected by colostral antibodies until 3-4 months of age so infection before this point is uncommon.

Outbreaks are most often seen in cattle between '''6 and 18 months''' of age though all ages of cattle are susceptible. Calves are usually protected by colostral antibodies until 3-4 months of age so infection before this point is uncommon.

Signs of IBR include '''coughing, serous nasal discharge, tachypnoea and dyspnoea'''. There may also be signs of increased lacrimation and a '''marked conjunctivitis'''. Coughing and sneezing are observed. The virus is excreted in the nasal secretions as early as 24 hours after infection. After an incubation period of 2 to 4 days, nasal secretions are more profuse and evolve from '''sero-mucous to mucopurulent discharge'''. The animal will usually be '''pyrexic''' and be weak, dull and depressed. It will usually have a reduced appetite and may show signs of weight loss. If in milk, the yield will be decreased. Young animals show ptyalism.

Signs of IBR include '''coughing, serous nasal discharge, tachypnoea and dyspnoea'''. There may also be signs of increased lacrimation and a '''marked conjunctivitis'''. Coughing and sneezing are observed. The virus is excreted in the nasal secretions as early as 24 hours after infection. After an incubation period of 2 to 4 days, nasal secretions are more profuse and evolve from '''sero-mucous to mucopurulent discharge'''. The animal will usually be '''pyrexic''' and be weak, dull and depressed. It will usually have a reduced appetite and may show signs of weight loss. If in milk, the yield will be decreased. Young animals show ptyalism.

IBR may cause '''abortion''' if susceptible cows or heifers are infected during pregnancy.  Abortion is observed between '''4 and 8 months of gestation'''. Early embryonic death can also occur. Abortion is a consequence of '''respiratory infection of pregnant cows'''. Viraemia allows the virus to enter the uterine artery and cross the placenta. Abortion is due to a '''lytic infection''' of the fetus. All internal organs of the fetus, especially the '''liver and renal cortex''', show foci of necrosis. A generalized multifocal necrosis is diagnosed.<ref> Smith, K. C (1997) '''Herpesviral abortion in domestic animals'''. Vet Journal, 153(3):253-268</ref> Infection of cows during the last trimester of gestation can lead to '''neonatal death''', and death of weak calves can occur during the first 2 weeks of life.<ref> Thiry, E., Detilleux, P., Vriese, A., Pirak, M., Pastoret, P-P (1984) '''Infectious bovine rhinotracheitis in the neonatal period: a review and a case report.''' Annales de Médecine Vétérinaire, 128(1):33-40; 25</ref>

IBR may cause '''abortion''' if susceptible cows or heifers are infected during pregnancy.  Abortion is observed between '''4 and 8 months of gestation'''. Early embryonic death can also occur. Abortion is a consequence of '''respiratory infection of pregnant cows'''. Viraemia allows the virus to enter the uterine artery and cross the placenta. Abortion is due to a '''lytic infection''' of the fetus. All internal organs of the fetus, especially the '''liver and renal cortex''', show foci of necrosis. A generalized multifocal necrosis is diagnosed.<ref> Smith, K. C (1997) '''Herpesviral abortion in domestic animals'''. ''Vet Journal'', 153(3):253-268</ref> Infection of cows during the last trimester of gestation can lead to '''neonatal death''', and death of weak calves can occur during the first 2 weeks of life.<ref> Thiry, E., Detilleux, P., Vriese, A., Pirak, M., Pastoret, P-P (1984) '''Infectious bovine rhinotracheitis in the neonatal period: a review and a case report.''' ''Annales de Médecine Vétérinaire'', 128(1):33-40; 25</ref>

'''Latent infection can occur''', the viral cells residing in the '''trigeminal nerve''', and infected cattle can then shed the virus intermittently.  

'''Latent infection can occur''', the viral cells residing in the '''trigeminal nerve''', and infected cattle can then shed the virus intermittently.  

== Pathology ==

== Pathology ==

'''Ulcers and redness''' are visible on the '''nasal mucosa''', in the pharynx and trachea. Lesions are usually restricted to the '''upper respiratory tract'''. [[Bronchitis]] and [[:Category:Pneumonia|pneumonia]] can also be observed, but usually as a consequence of secondary bacterial infections. Respiratory mucosae are red and oedematous, foci of ulcers are observed and some lesions are haemorrhagic<ref>Gibbs, E. P. J., Rweyemamu, M. M (1977) '''Bovine herpesviruses. Part I. Bovine herpesvirus 1.''' Veterinary Bulletin, 47:317-343.</ref> <ref name="Straub" />

'''Ulcers and redness''' are visible on the '''nasal mucosa''', in the pharynx and trachea. Lesions are usually restricted to the '''upper respiratory tract'''. [[Bronchitis]] and [[:Category:Pneumonia|pneumonia]] can also be observed, but usually as a consequence of secondary bacterial infections. Respiratory mucosae are red and oedematous, foci of ulcers are observed and some lesions are haemorrhagic.<ref>Gibbs, E. P. J., Rweyemamu, M. M (1977) '''Bovine herpesviruses. Part I. Bovine herpesvirus 1.''' ''Veterinary Bulletin', 47:317-343.</ref> <ref name="Straub" />

'''Infectious pustular vulvovaginitis (IPV) ''' and '''infectious pustular balanoposthitis (IPB)''' is a pustular inflammation causing the genital mucosa to become red and oedematous with '''vesicles and pustules evolving into ulcers.'''

'''Infectious pustular vulvovaginitis (IPV) ''' and '''infectious pustular balanoposthitis (IPB)''' is a pustular inflammation causing the genital mucosa to become red and oedematous with '''vesicles and pustules evolving into ulcers.'''

'''[[ELISA testing|ELISAs]]''' have also been developed to detect BHV-1 antibodies in '''bulk milk''', or in milk samples from individual cows. Milk ELISAs have been found to perform well when compared with standard serum ELISAs.

'''[[ELISA testing|ELISAs]]''' have also been developed to detect BHV-1 antibodies in '''bulk milk''', or in milk samples from individual cows. Milk ELISAs have been found to perform well when compared with standard serum ELISAs.

In IBR control programmes, serological diagnosis aims to identify latently infected animals. However, a few animals are seronegative latent carriers (SNLC), i.e. they are latently infected with BHV-1 without detectable antibodies. <ref>Lemaire, M., Meyer, G., Baranowski, E., Schynts, F., Wellemans, G., Kerkhofs, P., Thiry, E (2000) '''Effects of bovine herpesvirus type 1 infection in calves with maternal antibodies on immune response and virus latency'''. J Clin Microbiol, 38:1885-1894</ref>

In IBR control programmes, serological diagnosis aims to identify latently infected animals. However, a few animals are seronegative latent carriers (SNLC), i.e. they are latently infected with BHV-1 without detectable antibodies. <ref>Lemaire, M., Meyer, G., Baranowski, E., Schynts, F., Wellemans, G., Kerkhofs, P., Thiry, E (2000) '''Effects of bovine herpesvirus type 1 infection in calves with maternal antibodies on immune response and virus latency'''. ''J Clin Microbiol'', 38:1885-1894</ref>

== Treatment ==

== Treatment ==

<references/>

<references/>

Kaashoek, M. J., Moerman, A., Madic, J., Rijsewijk, F. A. M., Quak, J., Gielkens, A. L. J., Oirschot, J. Tvan (1994) '''A conventionally attenuated glycoprotein E-negative strain of bovine herpesvirus type 1 is an efficacious and safe vaccine.''' Vaccine, 12(5):439-444; 19

Kaashoek, M. J., Moerman, A., Madic, J., Rijsewijk, F. A. M., Quak, J., Gielkens, A. L. J., Oirschot, J. Tvan (1994) '''A conventionally attenuated glycoprotein E-negative strain of bovine herpesvirus type 1 is an efficacious and safe vaccine.''' ''Vaccine'', 12(5):439-444; 19

Karstad, L., Jessett, D. M., Otema, J. C., Drevemo, S (1974) '''Vulvovaginitis in wildebeest caused by the virus of infectious bovine rhinotracheitis''' J Wildlife Diseases, 10:392-396.

Karstad, L., Jessett, D. M., Otema, J. C., Drevemo, S (1974) '''Vulvovaginitis in wildebeest caused by the virus of infectious bovine rhinotracheitis''' ''J Wildlife Diseases'', 10:392-396.

Lemaire, M., Meyer, G., Baranowski, E., Schynts, F., Wellemans, G., Kerkhofs, P., Thiry, E (2000) '''Production of bovine herpesvirus type 1-seronegative latent carriers by administration of a live-attenuated vaccine in passively immunized calves'''. J Clin Microbiol, 38(11):4233-4238; 43 ref.

Lemaire, M., Meyer, G., Baranowski, E., Schynts, F., Wellemans, G., Kerkhofs, P., Thiry, E (2000) '''Production of bovine herpesvirus type 1-seronegative latent carriers by administration of a live-attenuated vaccine in passively immunized calves'''. ''J Clin Microbiol,'' 38(11):4233-4238; 43 ref.

Mars, M. H et al (2000) '''Airborne transmission of bovine herpesvirus 1 infections in calves under field conditions'''. Veterinary Microbiology, 76(1):1-13.

Mars, M. H et al (2000) '''Airborne transmission of bovine herpesvirus 1 infections in calves under field conditions'''. ''Veterinary Microbiology'', 76(1):1-13.

Mars, M. H., Bruschke, C. J. M., Oirschot, J. Tvan (199) '''Airborne transmission of BHV 1 [bovine herpesvirus 1], BRSV [bovine respiratory virus], and BVDV [bovine virus diarrhoea virus] among cattle is possible under experimental conditions'''. Veterinary Microbiology, 66(3):197-207; 33

Mars, M. H., Bruschke, C. J. M., Oirschot, J. Tvan (199) '''Airborne transmission of BHV 1 [bovine herpesvirus 1], BRSV [bovine respiratory virus], and BVDV [bovine virus diarrhoea virus] among cattle is possible under experimental conditions'''. ''Veterinary Microbiology,'' 66(3):197-207; 33

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OIE, 2004. '''Manual of Diagnostic Tests and Vaccines for Terrestrial Animals'''. Paris, France: ''World Organisation for Animal Health''. http://www.oie.int/eng/normes/mmanual/A_summry.htm. (accessed April 2011)

OIE, 2005. '''Terrestrial Animal Health Code'''. Paris, France: ''Office International Des Epizooties'', Chapter 2.3.5.  

OIE, 2009. '''World Animal Health Information Database - Version: 1.4'''. ''World Animal Health Information Database''. Paris, France: ''World Organisation for Animal Health''.  

OIE, 2009. '''World Animal Health Information Database - Version: 1.4'''. ''World Animal Health Information Database''. Paris, France: World Organisation for Animal Health.

Van, Oirschot, J. T., Kaashoek, M. J., Rijsewijk, F. A. M (1996) '''Advances in the development and evaluation of bovine herpesvirus 1 vaccines'''. ''Veterinary Microbiol'', 53(1/2):43-54; 60

Van, Oirschot, J. T., Kaashoek, M. J., Rijsewijk, F. A. M (1996) '''Advances in the development and evaluation of bovine herpesvirus 1 vaccines'''. Veterinary Microbiol, 53(1/2):43-54; 60

Wyler, R., Engels, M., Schwyzer, M (1989) '''Infectious Bovine Rhinotracheitis/Vulvovaginitis (BHV-1). In: Wittmann G, ed. Herpesvirus Diseases of Cattle, Horse and Pigs'''. Massachusetts, USA: ''Kluwer Academic Publishers'', 1-72.

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