| Line 1: |
Line 1: |
| − | *Causes [[Respiratory Bacterial Infections - Pathology#Melioidosis (Pseudoglanders)|melioidosis]] - endemic in Asia and Australia
| + | #redirect[[Melioidosis]] |
| − | *Primarily infects rodents
| + | |
| − | *Pathogenesis:
| + | [[Category:Pseudomonas_and_Burkholderia_species|C]] |
| − | **Infection via ingestion, inhalation or skin wounds from environment
| |
| − | **Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
| |
| − | **Strain virulence and host immunosuppression important
| |
| − | *Clinical infections:
| |
| − | **Opportunistic infection with stress and immunosuppression predisposing to disease
| |
| − | **Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
| |
| − | **Chronic, debilitating, progressive disease with long incubation period
| |
| − | **Many animal species susceptible
| |
| − | **Referred to as pseudoglanders in horses
| |
| − | *Diagnosis:
| |
| − | **Specimens: pus from abscesses, affected tissues, blood
| |
| − | **Fluorescent antibody technique on tissue smears
| |
| − | **Blood agar and MacConkey agar plates, incubated aerobically
| |
| − | **Colonies have musty smell
| |
| − | **Lactose fermentation on MacConkey
| |
| − | **Slide agglutination
| |
| − | **ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
| |
| − | *Treatment/control: slaughter of infected animals where exotic[[Category:Pseudomonas_and_Burkholderia_species]][[Category:Rodents]]
| |
| − | [[Category:To_Do_-_Bacteria]]
| |