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Line 1: − + + − ====Antigenicity====+ − *2 Canine Viruses: − **Canine Parvovirus 1 ('''CPV1'''): avirulent, ubiquitous in canine population − **Canine Parvovirus 2 ('''CPV2'''): new virus emerged in the late 1970's − *Antigenic variants occur − ====Hosts==== − *Dogs − *CPV 2a/2b can cause disease in cats − + − *Oropharyngeal infection followed by '''viremia''' − *2 distinct syndromes: − #'''Myocarditis''' in puppies aged 3-8 weeks − #*Virus targets rapidly dividing myocardium − #*Sudden death, '''fading puppy''' syndrome − #*Now rare due to widespread passive immunity − #'''Enteritis''' in puppies >8 weeks of age − #*Virus targets intestinal crypts − #*Villi shorten, then destruction of cypt cells − #*Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis − #*High morbidity, low mortality (10%) − ====Epidemiology====+ − + − + − + − *HA or ELISA for virus − + − *Vaccination, usually in combination with distemper and hepatitis. With first vaccination at 8-10 weeks and the second vaccination two weeks after the first, 10-12 weeks. + − *Thorough disinfection after disease+ − + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +
→Pathogenesis
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== Introduction ==
Until 1978 Parvovirus enteritis was totally unknown in dogs - it was first seen in dogs in Australia where it appeared very similar but perhaps slightly worse than the [[Feline Panleucopenia|disease seen in the cat]]. Research revealed a new and distinct disease, but the virus is very closely related to the feline virus; viral DNA is 98% homologous to the feline virus. Clinically, the virus causes enteritis mainly affecting the [[Small Intestine Overview - Anatomy & Physiology|small intestine]] in young dogs over 6 weeks old and [[Myocarditis|myocarditis]] in puppies. The virus is transmitted orally. Vaccines are very effective, but the virus is hardy and survives for a protracted time in the environment.
====Pathogenesis====
== Antigenicity ==
Two canine viruses have been identified, these are:
*'''Orofecal''' transmission
*Canine Parvovirus 1 ('''CPV1'''): avirulent and ubiquitous in the canine population
*Host range is controlled by only a few amino acids
*Canine Parvovirus 2 ('''CPV2'''): a new virus that emerged in the late 1970's. Antigenic variants do naturally occur.
====Diagnosis====
== Pathogenesis ==
====Control====
Oropharyngeal infection is followed by '''viraemia'''. Subsequently there are two distinct syndromes depending on the age of the animal:
#'''Myocarditis''' in puppies aged 3-8 weeks - the virus targets rapidly dividing myocardium leading to sudden death, or '''fading puppy''' syndrome. This is now rare due to widespread passive immunity.
[[Category:Parvoviridae]][[Category:Dog]]
#'''Enteritis''' in puppies 6 weeks of age. The virus targets intestinal crypts, causing the villi to shorten and the destruction of crypt cells, leading to gray, persistent, foul-smelling diarrhoea or [[Gastroenteritis, Haemorrhagic|hemorrhagic enteritis]]. CPV has a high morbidity but low mortality (10%) rate.
== Diagnosis ==
Often the clinical signs plus history, signalment and lack of vaccination is very indicative of the virus. [[Agglutination|Haemagglutination]] or [[ELISA testing|ELISA]] should be performed to confirm viral infection. Viral antigen can be detected in the faeces by the red cell agglutination test. [[Immunofluorescence]] and serology can also be used to diagnose this disease.
== Treatment and Control ==
In an outbreak, affected dogs need to be kept isolated. Supportive care needs to be given such as intravenous [[:Category:Fluid Therapy|fluid therapy]]. [[Antibiotics]] are sometimes given to protect against or treat any secondary bacterial infections that may ensue.
Vaccination is widely available and is recommended for puppies. The vaccine is given in combination with [[Distemper]], [[Infectious Canine Hepatitis|Hepatitis]] and [[Canine Parainfluenza - 2|Parainfluenza viruses]]. First vaccine is given at 8-10 weeks and the second vaccination two weeks after the first, 10-12 weeks of age. Earlier vaccinations can be given where breeders are known to have CPV on the premises.
{{Learning
|Vetstream = [https://www.vetstream.com/canis/Content/Bug/bug00213.asp, Canine parvovirus]<br>
[https://www.vetstream.com/canis/Content/Disease/dis01005.asp, CPV 1 - disease]<br>[https://www.vetstream.com/canis/Content/Disease/dis01007.asp, CPV 2 - disease)
|full text = [http://www.cabi.org/cabdirect/FullTextPDF/2009/20093115250.pdf '''Canine parvovirus: an emerging, re-emerging, significant pathogen of dogs.''' Kapil, S.; The North American Veterinary Conference, Gainesville, USA, Small animal and exotics. Proceedings of the North American Veterinary Conference, Orlando, Florida, USA, 17-21 January, 2009, 2009, pp 650-651, 3 ref.]
}}
== References ==
Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company
Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.
Tilley, L.P. and Smith, F.W.K.(2004)The 5-minute Veterinary Consult (Third edition) Lippincott, Williams & Wilkins.
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[[Category:Parvoviridae]] [[Category:Cardiovascular_Diseases_-_Dog]] [[Category:Dog_Viruses]] [[Category:Intestinal_Diseases_-_Dog]] [[Category:Enteritis, Viral]][[Category:Expert_Review]]