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=Introduction=
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{{frontpage
Asfarviridae receives it's name from [[African Swine Fever|'''A'''frican '''S'''wine '''F'''ever virus]], which is derived from any of this family of virusesASF is a serious exotic virus that should not be confused with [[Classical Swine Fever]].
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|pagetitle =Asfarviridae
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|pagebody = Asfarviridae contains asfivirus, which is the virus of African Swine FeverThis is a serious exotic virus that should not be confused with [[Classical Swine Fever]].
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|contenttitle =Content
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|contentbody =<big><b>
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=Morphology=
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<categorytree mode=pages>Asfarviridae</categorytree>
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|logo =ASF logo.jpg
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}}
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==Morphology==
 
*Large, enveloped, icosahedral, '''cytoplasmic''' DNA virus
 
*Large, enveloped, icosahedral, '''cytoplasmic''' DNA virus
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=Virulence and Pathogenesis=
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==Virulence and Pathogenesis==
 
*Infects either '''upper respiratory tract''' or '''skin''' via '''ticks'''
 
*Infects either '''upper respiratory tract''' or '''skin''' via '''ticks'''
*Enters bloodstream in [[Monocytes - WikiBlood|monocytes]]
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*Enters bloodstream in [[Monocytes|monocytes]]
 
*Reaches viscera and bone marrow within days
 
*Reaches viscera and bone marrow within days
 
*Induces a '''clotting defect''' and '''hemolysis''' in red blood cells
 
*Induces a '''clotting defect''' and '''hemolysis''' in red blood cells
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*General cell signal transduction is blocked, decreasing non-specific immunity
 
*General cell signal transduction is blocked, decreasing non-specific immunity
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''Acute Virus (Africa)''
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*Clinical Signs:
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**Nasal discharge, diarrhoea, reddening of the skin
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*Death within 7 days
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*PM: widespread internal hemorrhage
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''Subacute Virus (Europe)''
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*PM: Petechial hemorrhages may be seen under kidney capsule
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*Mortality: 30-70%
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*Survivors may lose body condition, have skin ulcers and joint swelling
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=Epidemiology=
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*Can persist on infected premises for months
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*Subacute recovered pigs become antibody-positive carriers
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*Transfer:
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**Africa: vertical transfer between '''soft ticks'''
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**Europe/Africa: '''direct contact''' with carrier pigs, '''aerosol''', infected swill, etc.
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=Diagnosis=
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*Mortalities with widespread hemorrhage, particularly in lymph nodes
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*Test to distinguish from  [[Classical Swine Fever]] and [[Porcine Circoviruses]]
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*Immunofluorescence
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*PCR
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=Control=
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[[Category:Viral Organisms]]
*No vaccine is available
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[[Category:To_Do_-_Clinical/Viruses]]
Prevention:
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*Boiling swill
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*Isolation of sick pigs, domestic pigs from wild pigs
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*Keep pigs on concrete, not soil (to lessen tick contact)
 
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