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− | =Introduction= | + | {{frontpage |
− | Asfarviridae receives it's name from [[African Swine Fever|'''A'''frican '''S'''wine '''F'''ever virus]], which is derived from any of this family of viruses. ASF is a serious exotic virus that should not be confused with [[Classical Swine Fever]]. | + | |pagetitle =Asfarviridae |
| + | |pagebody = Asfarviridae contains asfivirus, which is the virus of African Swine Fever. This is a serious exotic virus that should not be confused with [[Classical Swine Fever]]. |
| + | |contenttitle =Content |
| + | |contentbody =<big><b> |
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− | =Morphology= | + | <categorytree mode=pages>Asfarviridae</categorytree> |
| + | |logo =ASF logo.jpg |
| + | }} |
| + | |
| + | ==Morphology== |
| *Large, enveloped, icosahedral, '''cytoplasmic''' DNA virus | | *Large, enveloped, icosahedral, '''cytoplasmic''' DNA virus |
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− | =Virulence and Pathogenesis= | + | ==Virulence and Pathogenesis== |
| *Infects either '''upper respiratory tract''' or '''skin''' via '''ticks''' | | *Infects either '''upper respiratory tract''' or '''skin''' via '''ticks''' |
− | *Enters bloodstream in [[Monocytes - WikiBlood|monocytes]] | + | *Enters bloodstream in [[Monocytes|monocytes]] |
| *Reaches viscera and bone marrow within days | | *Reaches viscera and bone marrow within days |
| *Induces a '''clotting defect''' and '''hemolysis''' in red blood cells | | *Induces a '''clotting defect''' and '''hemolysis''' in red blood cells |
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| *General cell signal transduction is blocked, decreasing non-specific immunity | | *General cell signal transduction is blocked, decreasing non-specific immunity |
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− | ''Acute Virus (Africa)''
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− | *Clinical Signs:
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− | **Nasal discharge, diarrhoea, reddening of the skin
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− | *Death within 7 days
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− | *PM: widespread internal hemorrhage
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− | ''Subacute Virus (Europe)''
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− | *PM: Petechial hemorrhages may be seen under kidney capsule
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− | *Mortality: 30-70%
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− | *Survivors may lose body condition, have skin ulcers and joint swelling
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− | =Epidemiology=
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− | *Can persist on infected premises for months
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− | *Subacute recovered pigs become antibody-positive carriers
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− | *Transfer:
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− | **Africa: vertical transfer between '''soft ticks'''
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− | **Europe/Africa: '''direct contact''' with carrier pigs, '''aerosol''', infected swill, etc.
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− | =Diagnosis=
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− | *Mortalities with widespread hemorrhage, particularly in lymph nodes
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− | *Test to distinguish from [[Classical Swine Fever]] and [[Porcine Circoviruses]]
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− | *Immunofluorescence
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− | *PCR
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− | =Control=
| + | [[Category:Viral Organisms]] |
− | *No vaccine is available
| + | [[Category:To_Do_-_Clinical/Viruses]] |
− | Prevention:
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− | *Boiling swill
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− | *Isolation of sick pigs, domestic pigs from wild pigs
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− | *Keep pigs on concrete, not soil (to lessen tick contact)
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