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Category:Oesophagus - Pathology (view source)

Revision as of 11:21, 28 May 2010

1,164 bytes removed , 11:21, 28 May 2010

→‎Key-Gaskell syndrome

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====[[Myasthenia Gravis]]====

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~~====Key-Gaskell syndrome====~~

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*Autonomic polyganglioneuropathy in cats

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*Abnormal function of the sympathetic and parasympathetic system.

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*Whole autonomic system involved – affected animals usually die.

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**Similar to [[Intestine Physical Disturbances - Pathology#Equine dysautonomia, or grass sickness|grass sickness]] in horses.

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~~=====Clinical=====~~

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*Cats show:

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**Mega-oesophagus

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**Dilated pupils

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**Whole gut is involved (very little peristalsis)

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**Constipation.

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*Generalised autonomic effects:

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**Reduced salivation

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**Reduced lachrymation

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**Bradycardia

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**Constipation

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**Pupillary dilatation

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~~=====Pathology=====~~

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*Histologically there is marked reduction in the number of neurones in all autonomic ganglia in the ventral horn of all levels of spinal cord accompanied by proliferation of non-neuronal cells.

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*Similar changes in brain stem nuclei of cranial nerves.

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~~=====Pathogenesis=====~~

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*Acquired disease - outbreaks occurred in the past, now only occasionally seen but seems to be getting more common again.

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*Possibly toxic cause.

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*Possibly in dry food or in vaccine?

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*Agent not really known, but produces general damage to autonomic nervous system.

===Hypersensitivity===

Bara

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