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| − | ===''Burkholderia pseudomallei=== | + | ===''[[Burkholderia pseudomallei]]=== |
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| − | *Causes [[Respiratory Bacterial Infections - Pathology#Melioidosis (Pseudoglanders)|melioidosis]] - endemic in Asia and Australia
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| − | *Primarily infects rodents
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| − | *Pathogenesis:
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| − | **Infection via ingestion, inhalation or skin wounds from environment
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| − | **Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
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| − | **Strain virulence and host immunosuppression important
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| − | *Clinical infections:
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| − | **Opportunistic infection with stress and immunosuppression predisposing to disease
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| − | **Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
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| − | **Chronic, debilitating, progressive disease with long incubation period
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| − | **Many animal species susceptible
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| − | **Referred to as pseudoglanders in horses
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| − | *Diagnosis:
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| − | **Specimens: pus from abscesses, affected tissues, blood
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| − | **Fluorescent antibody technique on tissue smears
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| − | **Blood agar and MacConkey agar plates, incubated aerobically
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| − | **Colonies have musty smell
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| − | **Lactose fermentation on MacConkey
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| − | **Slide agglutination
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| − | **ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
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| − | *Treatment/control: slaughter of infected animals where exotic
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| | [[Category:Bacteria]][[Category:Gram_negative_bacteria]][[Category:Rods]] | | [[Category:Bacteria]][[Category:Gram_negative_bacteria]][[Category:Rods]] |