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| | **(N.B Tolerant state exists when considering serology.) | | **(N.B Tolerant state exists when considering serology.) |
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| − | ===[[Herpesviridae#Malignant Catarrhal Fever|Malignant catarrhal fever]]=== | + | ===[[Malignant Catarrhal Fever]]=== |
| − | Postgrad material... [[Postgraduate / Certificate_Material for WikiPath]]
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| − | *Caused by a [[herpesviridae#gammaherpesviruses|gammaherpes virus]].
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| − | *Cattle, deer and antelope
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| − | *Not all that common in UK.
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| − | ====Clinical====
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| − | *Affects whole body but especially evident clinically in face and mouth.
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| − | *Sporadic and often seen in animals mixing with sheep(carriers).
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| − | *In parts of Africa see long outbreaks (diff serotypes) carried by Wildebeest.
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| − | *In deer produces very serious outbreaks, probably primarily sheep virus.
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| − | *Often youngish animal 6 months to 1 year. [[Image:MCF1.gif|right|thumb|125px|<small><center>Sever Oculo-nasal Discharge of MCF (Courtesy of Alun Williams (RVC))</center></small>]]
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| − | *Invariably fatal.
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| − | *Show fever and [[Intestine Diarrhoea - Pathology|diarrhoea]] with severe oculo-nasal discharge.
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| − | *Not eating, dull with ulcers on muzzle may spread to rest of face with brown exudate.
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| − | *Ulcers also on [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]], dental pad, and [[Cheeks - Anatomy & Physiology|cheeks]] that regularly become secondarily infected.[[Image:MCF2.gif|right|thumb|125px|<small><center>Fissures on tongue (no vesicles) in MCF (Courtesy of Alun Williams (RVC))</center></small>]]
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| − | *Skin becomes thickened and may peel.
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| − | *Conjunctivitis and corneal oedema / opacity (keratitis or "blue eye" - characteristic feature.)
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| − | *Often develop nervous signs.
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| − | *All [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] become very enlarged.
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| − | ====Pathology====
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| − | *Lymph nodes completely replaced by [[Lymph Nodes - Anatomy & Physiology#Follicles|lymphoblasts]] - similar to [[lymphosarcoma]]; synonym lymphoma. (resembles lymphotropic herpes virus such as [[Epstein Barr]])
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| − | *Also vasculitis with medial necrosis of blood vessels throughout body with infiltration of walls of vessels by [[Lymphocytes - WikiBlood|lymphocytes]].
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| − | *Ulcers are due to hypoxia of epithelium resulting from vascular lesions.
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| | ==Vesicular Pathology== | | ==Vesicular Pathology== |