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Complement Associated Diseases (view source)
Revision as of 10:11, 6 September 2007
, 10:11, 6 September 2007→Complement Fixation
* The central event in complement activation is the hydrolysis of the major complement protein, C3.
* The central event in complement activation is the hydrolysis of the major complement protein, C3.
** C3 is a large 2-chain molecule.
** C3 is a large 2-chain molecule.
** Hydrolysis results in the removal of a small peptide, C3a.
** Hydrolysis results in the removal of a small peptide, C3a (which itself is pro-inflammatory).
*** This leaves C3b.
*** This leaves C3b.
**** C3b is highly reactive but very short-lived.
**** C3b is highly reactive but very short-lived.