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| {{Taxobox | | {{Taxobox |
| |name = ''Cowdria ruminantium'' | | |name = ''Cowdria ruminantium'' |
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| |species = ''C. ruminantium'' | | |species = ''C. ruminantium'' |
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− | [[File:Heartwater 1.jpg|thumb|200px|right|Pulmonary oedema in goat with heartwater. Copyright AFSPH Iowa State.]]
| + | Also Known As: '''''Heartwater — Ehrlichiosis — Nintas (South Africa)''''' |
− | [[File:Heartwater 2|thumb|200px|right|''C. ruminantium'' in neutrophil from peripheral blood smear of a goat with heartwater. Copyright CFSPH Iowa State.]]
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− | Also Known As '''''– Cowdriosis – Heartwater – Ehrlichiosis – Nintas (South Africa)''''' | + | Caused by: '''''Cowdria ruminantium''''' Also known as: '''''Rickettsia ruminantium''''' |
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− | Caused by – ''Cowdria ruminantium'' AKA [[Rickettsiales | Rickettsia]] ruminantium
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| ==Introduction== | | ==Introduction== |
− | C. ruminantium is a '''[[Bacteria | bacterial]] gram negative coccal''' pathogen causing the '''[[Tick Disease Transmission | tickborne]] disease “Heartwater”''' in ruminants in '''Subsaharan Africa'''. Animals often acquire the disease when moved on to heartwater infected grazing. | + | ''C. ruminantium'' is a '''[[Bacteria | bacterial]] gram negative coccal''' pathogen causing the '''[[Tick Disease Transmission |tickborne]] disease “Heartwater”''' in ruminants in '''Subsaharan Africa'''. Animals often acquire the disease when moved on to heartwater infected grazing. |
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| It is an '''intracellular bacteria''', residing in endothelial cells and affecting the cardiovascular, respiratory and neurological systems. | | It is an '''intracellular bacteria''', residing in endothelial cells and affecting the cardiovascular, respiratory and neurological systems. |
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− | Cowdriosis has a huge economic impact in Africa, both in direct losses and as an obstruction to the improvement of breeding stock due to the susceptibility of introduced high producing breeds.<ref> Uilenberg, G.(1982). Disease problems associated with the introduction of European cattle in the tropics. Proc 12th World Cong Diseases Cattle, The Netherlands, 1025-1032</ref> | + | Cowdriosis has a huge economic impact in Africa, both in direct losses and as an obstruction to the improvement of breeding stock due to the susceptibility of introduced high producing breeds.<ref> Uilenberg, G. (1982) '''Disease problems associated with the introduction of European cattle in the tropics. '''''Proc 12th World Cong Diseases Cattle, The Netherlands, ''1025-1032</ref> |
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| + | Cowdriosis is '''notifiable''' to the World Organisation for Animal Health [http://www.oie.int/ (OIE)]. |
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− | Cowdriosis is '''notifiable''' to the World Organisation for Animal Health [http://www.oie.int/ (OIE)]
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| ==Distribution== | | ==Distribution== |
| Cowdriosis occurs across the African continent, particularly in '''South Africa'''. | | Cowdriosis occurs across the African continent, particularly in '''South Africa'''. |
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− | Cowdriosis is transmitted by '''bont [[Ticks | ticks]]''', mainly of the ''Amblyomma'' genus (''A. variegatum'' and ''A. hebraeum'') but also ''Rhipicephalus'', ''Hyalomma'', and ''Glossina'' species and the ''[[Sarcoptes]] scabei'' mite. Both adults and nymphs of tick species can transmit disease. | + | Cowdriosis is transmitted by '''bont [[Ticks |ticks]]''', mainly of the [[Amblyomma spp.|''Amblyomma'' genus]] (''A. variegatum'' and ''A. hebraeum'') but also [[Rhipicephalus spp.|''Rhipicephalus'']], [[Hyalomma spp.|''Hyalomma'']], and ''Glossina'' species and the ''[[Sarcoptes|Sarcoptes scabei]]'' mite. Both adults and nymphs of tick species can transmit disease. |
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− | Heartwater is therefore also a risk for countries where the Amblyomma tick is present, such as mainland America, Asia and the Caribbean, although disease is not at present. | + | Heartwater is therefore also a risk for countries where the ''Amblyomma'' tick is present, such as mainland America, Asia and the Caribbean, although disease may cutrently not be. |
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| ''C. ruminantium'' develops and replicates within both its mammalian and invertebrate hosts. | | ''C. ruminantium'' develops and replicates within both its mammalian and invertebrate hosts. |
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| Although speculated to be potentially zoonotic, there is no evidence of cowdriosis affecting humans. | | Although speculated to be potentially zoonotic, there is no evidence of cowdriosis affecting humans. |
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| ==Signalment== | | ==Signalment== |
| Cowdriosis affects a wide range of domestic and wild ruminants, although not all develop clinical disease. Clinical disease is most common in '''young animals.''' | | Cowdriosis affects a wide range of domestic and wild ruminants, although not all develop clinical disease. Clinical disease is most common in '''young animals.''' |
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− | ''Bos indicus'' (zebu) cattle appear more '''resistant''' than European breeds<ref> Uilenberg, G. (1983). '''Heartwater (Cowdria ruminantium infection): current status.''' Adv Vet Sci Comp Med, 27:427-480</ref> | + | ''Bos indicus'' (zebu) cattle appear more '''resistant''' than European breeds<ref> Uilenberg, G. (1983) '''Heartwater (''Cowdria ruminantium ''infection): current status.''' ''Adv Vet Sci Comp Med'', 27:427-480</ref> |
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| ==Clinical Signs== | | ==Clinical Signs== |
| Clinical signs are attributable to '''increased vascular permeability''' due to '''vascular endothelial cell invasion''' and consequent oedema and hypovolaemia: | | Clinical signs are attributable to '''increased vascular permeability''' due to '''vascular endothelial cell invasion''' and consequent oedema and hypovolaemia: |
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| '''Head tilt, tremors''', coma, circling, abnormal reflexes, '''hyperaesthesia, aggression''', head pressing, depression, nystagmus, mydriasis and blindness. | | '''Head tilt, tremors''', coma, circling, abnormal reflexes, '''hyperaesthesia, aggression''', head pressing, depression, nystagmus, mydriasis and blindness. |
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− | Animals display a '''high fever''' which my progress to hypothermia. They gradually stop feeding and behaviour changes. | + | Animals display a '''high fever''' which may progress to hypothermia. They gradually stop feeding and their behaviour changes. |
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| Cowdriosis can also cause reproductive and gastrointestinal disease. | | Cowdriosis can also cause reproductive and gastrointestinal disease. |
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| Various factors such as species, breed, age, natural resistance, vector efficiency and immune status dictate whether clinical disease develops and its severity. | | Various factors such as species, breed, age, natural resistance, vector efficiency and immune status dictate whether clinical disease develops and its severity. |
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| ==Diagnosis== | | ==Diagnosis== |
− | On '''post-mortem examination''', a '''light yellow [[Transudate | transudate]]''' that '''coagulates on exposure to air''' is often found within the '''thorax, [[Pericardial Pathology | pericardium]] and abdomen.''' Volume may vary but may be several litres in cattle. | + | On '''post-mortem examination''', a '''light yellow [[Transudate | transudate]]''' that '''coagulates on exposure to air''' is often found within the '''thorax, [[Pericardial - Pathology |pericardium]] and abdomen.''' Volume may vary but may be several litres in cattle. |
− | Most fatal cases will display the '''hydropericardium''' that gives the disease its common name, although this is seen more commonly in sheep and goats than cattle <ref> Henning, M. W. (1956) '''Heartwater'''. In: Anim Dis S Africa, ed 3. South Africa: ''Central News Agency Ltd'', 1155-1178</ref> | + | Most fatal cases will display the '''hydropericardium''' that gives the disease its common name, although this is seen more commonly in sheep and goats than cattle. <ref> Henning, M. W. (1956) '''Heartwater'''. In: Anim Dis S Africa, ed 3. South Africa: ''Central News Agency Ltd'', 1155-1178</ref> |
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− | '''Pulmonary oedema''' and mucosal congestion are regularly seen along with '''frothy fluid''' in the airways and cut surfaces of the [[Lungs - Anatomy & Physiology | lungs]]. | + | '''Pulmonary oedema''' and mucosal congestion are regularly seen along with '''frothy fluid''' in the airways and cut surfaces of the [[Lungs - Anatomy & Physiology |lungs]]. |
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− | The [[Spleen | spleen]] may be enlarged and pulpy in consistency. | + | The [[Spleen |spleen]] may be enlarged and pulpy in consistency. |
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− | Although neurological signs are often sttributed to '''cerebral oedema''', this is not always obvious macroscopically although in some cases the brain and '''gyri''' may be strikingly swollen and/or petechiated. | + | Although neurological signs are often attributed to '''cerebral oedema''', this is not always obvious macroscopically although in some cases the brain and '''gyri''' may be strikingly swollen and/or petechiated. |
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| The organism may be visible in '''smears''' of peripheral '''blood''' or the '''buffy coat'''. | | The organism may be visible in '''smears''' of peripheral '''blood''' or the '''buffy coat'''. |
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| '''Control''' of exposure to '''bont ticks''', whether total or strategic allowing a level of immunity to develop, is also vital but often difficult. It can be achieved through dipping with [[Ectoparasiticides | ectoparasiticides]]. | | '''Control''' of exposure to '''bont ticks''', whether total or strategic allowing a level of immunity to develop, is also vital but often difficult. It can be achieved through dipping with [[Ectoparasiticides | ectoparasiticides]]. |
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| + | {{Learning |
| + | |literature search = [http://www.cabdirect.org/search.html?q=title%3A+Cowdriosis Cowdriosis Publications] |
| + | |flashcards = [[Cowdriosis Flashcards]] |
| + | }} |
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| ==References== | | ==References== |
| <references/> | | <references/> |
− | Animal Health & ProductIon Compendium, '''Cowdria ruminantium datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
| + | {{CABI source |
| + | |datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=87241&loadmodule=datasheet&page=2144&site=160 cowdriosis] and [http://www.cabi.org/ahpc/Default.aspx?site=160&page=2144&LoadModule=datasheet&CompID=3&dsID=87240 ''Cowdria ruminantium''] |
| + | |date =06 June 2011 |
| + | }} |
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− | Animal Health & ProductIon Compendium, '''Cowdriosis datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
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− | [[Category:Rickettsiales]][[Category:Cattle Bacteria]][[Category:Sheep Bacteria]][[Category:Goat Bacteria]]
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− | [[Category:To Do - CABI review]] | + | [[Category:Cardiovascular Diseases - Cattle]][[Category:Neurological Diseases - Cattle]][[Category:Respiratory Diseases - Cattle]] |
| + | [[Category:CABI Expert Review]][[Category:CABI AHPC Pages]] |
| + | [[Category:Nick L]] |
| + | [[Category:Cardiology Section]] |