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*Over 19 species
 
*Over 19 species
**''C. neoformans'' only major pathogen
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**''[[Cryptococcus neoformans|Cryptococcus neoformans]]'' only major pathogen
    
*Worldwide
 
*Worldwide
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*May be a primary pathogen or opportunistic
 
*May be a primary pathogen or opportunistic
   −
*Targets the [[Cardiorespiratory System - Anatomy & Physiology|respiratory system]]
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*Targets the [[Cardiorespiratory System Overview - Anatomy & Physiology|respiratory system]]
**Including the [[Paranasal sinuses - Anatomy & Physiology|paranasal sinuses]]
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**Including the [[Paranasal Sinuses - Anatomy & Physiology|paranasal sinuses]]
 
**Also can be systemic, cutaneous, visceral, skeletal or ocular
 
**Also can be systemic, cutaneous, visceral, skeletal or ocular
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*Affects the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] of dogs and cats
 
*Affects the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] of dogs and cats
**[[Paranasal sinuses - Anatomy & Physiology|paranasal sinuses]] and [[Pharynx - Anatomy & Physiology|pharynx]] can be infected with dissemination to the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] and other tissues
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**[[Paranasal Sinuses - Anatomy & Physiology|paranasal sinuses]] and [[Pharynx - Anatomy & Physiology|pharynx]] can be infected with dissemination to the [[Nervous and Special Senses - Anatomy & Physiology#Central Nervous System (CNS)|CNS]] and other tissues
***E.g. [[Lungs - Anatomy & Physiology|Lungs]], [[Urinary System - Anatomy & Physiology#The Kidney|kidneys]] and [[Joints - Anatomy & Physiology|joints]]
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***E.g. [[Lungs - Anatomy & Physiology|Lungs]], [[Urinary System Overview - Anatomy & Physiology#The Kidney|kidneys]] and [[Joints - Anatomy & Physiology|joints]]
 
**Also causes subcutaneous granulomas
 
**Also causes subcutaneous granulomas
 
**The tip of the nose is a common site of infection in cats
 
**The tip of the nose is a common site of infection in cats
 
***See [[Respiratory Fungal Infections - Pathology#In Cats|here]]
 
***See [[Respiratory Fungal Infections - Pathology#In Cats|here]]
   −
*Causes myxoma-like lesions of the [[Lungs - Anatomy & Physiology|lung]] and [[Lips - Anatomy & Physiology|lip]] in horses
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*Causes myxoma-like lesions of the [[Lungs - Anatomy & Physiology|lung]] and [[Lips|lip]] in horses
    
*Causes cryptococcal meningitis in humans
 
*Causes cryptococcal meningitis in humans
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*Antigen and antibody should be tested for as [[Immunoglobulins|antibody]] formed by the body is soon overwhelmed and neutralised by abundent polysaccharide antigen from the capsule in active, systemic infections
 
*Antigen and antibody should be tested for as [[Immunoglobulins|antibody]] formed by the body is soon overwhelmed and neutralised by abundent polysaccharide antigen from the capsule in active, systemic infections
**Latex agglutination for [[Adaptive Immune System - WikiBlood#Actions of the Adaptive Immune System|antigen]], complement fixation, ELISA and IFAT can be used
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**Latex agglutination for [[Adaptive Immune System - Overview#Actions of the Adaptive Immune System|antigen]], complement fixation, ELISA and IFAT can be used
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{{Learning
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|Vetstream = [https://www.vetstream.com/felis/Content/Disease/dis02453 Cryptococcosis - Felis]
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|flashcards = [[Yeast-like_Fungi_-_Flashcards#Cryptococcosis|Cryptococcosis Flashcards]]
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}}
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===''Cryptococcus neoformans''===
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[[Category:Respiratory Fungal Infections]]
 
  −
*[[Yeast-like fungi|''Cryptococcus neoformans'']]
  −
*Causes a [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|granulomatous rhinitis]], gelatinous exudate, [[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous pneumonia]]
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*Nodules or destructive masses which often result in facial swelling
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*In severe cases, extension from nasal cavity to involve skin and oral mucosa can occur
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*Can invade through adjacent structures, eg: through the cribiform plate into the brain! These cases therefore can present as a primary neurological disease.
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*Microscopic:
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**Large number of fungi and only few macrophages, lymphocytes and giant cells
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[[Category:Yeast-like_Fungi]]
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[[Category:To_Do_-_Fungi]]
 
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