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==Description==
Also known as: '''''Demodecosis — Red Mange'''''
An inflammatory parasitic disease of dogs and cats caused by [[Demodex]]. The mites are host-specific and can occur in dogs, cats, cattle, sheep, goats, pigs and horses. There has to be an increased number of immature mites to classify as an infestation. The mite is transmitted from dam to offspring during nursing. The mites live in hair follicles and infestation may lead to secondary bacterial infection and furunculosis.
==Introduction==
An inflammatory parasitic disease of dogs and cats caused by ''[[Demodex]]''. The mites are host-specific and can occur in dogs, cats, cattle, sheep, goats, pigs and horses. There has to be an increased number of immature mites to classify as an infestation. The mite is transmitted from dam to offspring during nursing. The mites live in hair follicles and infestation may lead to secondary bacterial infection and furunculosis.
==Signalment==
==Signalment==
Commonly affects the dog and more rarely the cat.
Commonly affects the dog and more rarely the cat.
'''Breed predilections'''
'''Breed predilections''':
Demodicosis is usually a disease of short haired dogs and is more common in pedigree breeds. Within [[Canine Breeds - WikiNormals|dog breeds]], the Staffordshire bull terrier, German Shepherd dog, Old English Sheepdog, Collies and dalmations are at risk. Additionally it has been reported that there is an increased incidence in Siamese and Burmese cats.
Demodicosis is usually a disease of short haired dogs and is more common in pedigree breeds. Within [[Canine Breeds - WikiNormals|dog breeds]], the Staffordshire bull terrier, German Shepherd dog, Old English sheepdog, Collies and Dalmatians are at risk. Additionally within [[Feline Breeds - WikiNormals|cat breeds]] it has been reported that there is an increased incidence in Siamese and Burmese cats.
'''Age predilections'''
'''Age predilections''':
Often animals less than 12 months of age of affected although adult onset is recognised.
Often animals less than 12 months of age are affected although adult onset is recognised.
==Clinical Signs==
==Clinical Signs==
Crusting, hair loss, grey hyperpigmentation and plugged follicles are typical findings in animals suffering from demodicosis.
Crusting, hair loss, grey hyperpigmentation and plugged follicles are typical findings in animals suffering from demodicosis.
Dogs:
===Dogs===
May be localised or generalised in the dog.
May be localised or generalised.
'''Localised demodicosis:''' Typically seen in dogs 3-6 months of age and 90% of cases will heal spontaneously. Signs are of a mild non- pruritic alopecia in some cases erythema and a fine scale. Lesions are most commonly found on the head particularly around the periocular region and the forelimbs.
'''Localised demodicosis:''' Typically seen in dogs 3-6 months of age and 90% of cases will heal spontaneously. Signs are of a mild non- pruritic alopecia in some cases erythema and a fine scale. Lesions are most commonly found on the head particularly around the periocular region and the forelimbs.
'''Generalised demodicosis:'''
'''Generalised demodicosis:'''
Most commonly occurs in dogs between 3-12 months of age. Can be widespread from the beginning and lesions can range from multiple poorly circumscribed areas of erythema, alopecia and scale to generalised pustules often resulting in rupture of the hair follicle (furunculosis).
Most commonly occurs in dogs between 3-12 months of age. Can be widespread from the beginning and lesions can range from multiple poorly circumscribed areas of erythema, alopecia and scale to generalised pustules often resulting in rupture of the hair follicle (furunculosis).
A lymphadenopathy and pyrexia are also common features of generalised demodicosis. Pododemodicosis can occur with the generalised form and can persist after other lesions have resolved or appear in isolation. This manifests as erythema and secondary infection of the feet.
A lymphadenopathy and pyrexia are also common features. Pododemodicosis can occur with the generalised form and can persist after other lesions have resolved or appear in isolation. This manifests as erythema and secondary infection of the feet.
'''Adult Onset Demodicosis:''' Can present as generalised disease or focal alopecia . Onset in adulthood is often associated with internal disease such as ([[Hyperadrenocorticism|hyperadrenocorticism]], immunosuppression or neoplasia. Long term use of glucocorticoids in the West Highland white terrier has been associated with adult onset demodicosis.
===Cats===
Often multifocal alopecia particularly of the eyelids, periocular region, head and neck. Erythema scale and crust may be present with varying degrees of pruritus. Otodemodicosis which manifests as an erythematous ceruminous otitis has also been reported in the cat.
===Cattle===
Pea-sized nodules are present over the body. Each nodule contains several thousand mites. Affects hide quality and is economically important in Australia.
===Goat===
The disease is becoming more common in goats and it is similar to that in cattle.
===Horse, Pig, Sheep===
Demodicosis is rare in these species.
===Small Mammals===
[[Mites - Gerbils#Demodecosis|'''Gerbils''']]: Alopecia, scaliness and ulceration of the tail and hindlimbs. Normally in undernourished, debilitated, old, young or pregnant animals. Caused by ''Demodex merioni''.<br>
[[Mites - Hamsters#Demodicosis|'''Hamsters''']]: Moderate to severe alopecia that appears dry and scaly. Normally in animals over 1.5 years of age that are undernourished, immunosupressed or suffering from concurrent disease. Caused by ''Demodex criceti'' and ''Demodex aurati''.
==Diagnosis==
History and clinical signs will often indicate demodicosis. In all cases of adult onset demodicosis, a detailed history and medical investigation must be undertaken to identify an underlying systemic disease.
===Microscopic Exam===
Microscopic examination of deep skin scraping reveals the cigar-shaped adult [[Demodex| ''Demodex'']] mites (eight legs), larval forms (six legs) and lemon-shaped eggs in high numbers. Hair plucks can also demonstrate mites microscopically. As mites are often residents in normal skin, detecting mites on a skin scrape may not always provide a definitive diagnosis - results should be combined with the entire clinical picture. The absence of mites on multiple skin scrapes may allow you to rule out the disease.
==Laboratory Tests==
===Laboratory Tests===
Haematology and Biochemistry may be useful in identifying an underlying cause in adult onset demodicosis.
Haematology and Biochemistry may be useful in identifying an underlying cause in adult onset demodicosis.
==Biopsy==
===Biopsy===
Cutaneous biopsy may be necessary if lesions are chronic, granulomatous or fibrotic.
Cutaneous biopsy may be necessary if lesions are chronic, granulomatous or fibrotic.
==Treatment==
==Treatment==
Localised demodicosis in young dogs will often resolve spontaneously.
Localised demodicosis in young dogs will often resolve spontaneously.
In cases of generalised demodicosis: Amitraz (Aludex) should be used as a dip weekly until there is a resolution of clinical signs and skin scrapes are negative for the mite. It is advised to treat with benzoyl peroxide shampoo prior to amitraz treatment to increase exposure of the mites to the amitraz. Side effects of this treatment include lethargy, anorexia, depression, vomiting and diarrhoea.
A spot on treatment containing imidacloprid and moxidectin (advocate) is also licenced to treat demodicosis.
In cases of generalised demodicosis: Amitraz (Aludex, Intervet/Schering-Plough Animal Health) should be used as a dip weekly until there is a resolution of clinical signs and skin scrapes are negative for the mite. The mites are not easily accessible to acaricides due to their deep location in the skin and to aid amitraz penetration, clipping a dog's coat and washing with benzoyl peroxide shampoo prior to application is recommended. Side effects of this treatment include lethargy, anorexia, depression, vomiting and diarrhoea.
Any secondary pyoderma present on the animal must also be treated.
If the amitraz and imidacloprid-moxidecin combinations are ineffective ivermectin or milbemycin csan be given daily. this treatment is off-licence and requires informed owner consent as well as monitoring for signs of neurological side effects.
A spot on treatment containing imidacloprid and moxidectin (Advocate, Bayer) is also licenced to treat demodicosis. An alternative licensed product is an amitraz and metaflumizone spot on (Promeris Duo, Pfizer AH).
Any secondary pyoderma present on the animal must also be treated with appropriate antibiotics.
If the amitraz and imidacloprid-moxidecin combinations are ineffective or not tolerated ivermectin or milbemycin can be given daily. This treatment is off-licence and requires informed owner consent as well as monitoring of the animal for signs of neurological side effects.
==Prognosis==
==Prognosis==
Prognosis is good for localised cases. Generalised demodicosis is often managed medically however many cases are controlled rather than cured. Owners must be educated about the disease and be advised not to breed from animals with the generalised form.
Prognosis is good for localised cases. Generalised demodicosis is often managed medically however many cases are controlled rather than cured. Owners must be educated about the disease and be advised not to breed from animals with the generalised form.
Adult-onset dogs are often refractory to treatment.
Adult-onset dogs are often refractory to treatment.
{{Learning
|Vetstream = [https://www.vetstream.com/canis/Content/Bug/bug00050 Demodecosis in dogs]<br>[https://www.vetstream.com/canis/Content/Disease/dis02358.asp Demodectic mange in dogs]<br>[https://www.vetstream.com/canis/Content/Technique/teq00593.asp Skin scraping]
|flashcards = [[Cytology Q&A 18]]
|literature search = [http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28Dogs%29 Demodicosis in dogs]
==Diagnosis==
[http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28cats%29 Demodicosis in cats]
[http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28horses%29 Demodicosis in horses]
==Control==
[http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28cattle%29 Demodicosis in cattle]
[http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28sheep%29 Demodicosis in sheep]
[http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28goats%29 Demodicosis in goats]
[http://www.cabdirect.org/search.html?q=%28title%3A%28Demodicosis%29+OR+title%3A%28Demodex%29+OR+title%3A%28demodecosis%29%29+AND+od%3A%28pigs%29 Demodicosis in pigs]
}}
===From Pathology===
==References==
Forsythe, P (2007) '''Collection and interpretation of clinical samples for dermatological analysis''' ''In Practice 2007 29: 158-16''
Henfrey, J I (1990) '''Canine Demodecosis''' ''In Practice 1990 12: 187-19''
'''[[Demodicosis - Dog|Dogs]]'''
'''[[Demodicosis - Cat|Cats]]'''
Tilley, L.P, Smith, F.W.K. (2004) '''The 5-minute veterinary consult, canine and feline.''' (3rd edition). Lippincott Williams and Wilkins.
4th year BvetMed Dermatology Notes. RVC 2008
{{review}}
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[[Category:To_Do_-_Caz]]
[[Category:Expert_Review - Small Animal]][[Category:Dermatological Diseases - Dog]][[Category:Dermatological Diseases - Cat]]
[[Category:Dermatological Diseases - Cattle]][[Category:Dermatological Diseases - Sheep]][[Category:Dermatological Diseases - Pig]][[Category:Dermatological Diseases - Goat]]
[[Category:Dermatological Diseases - Horse]]
[[Category:Integumentary System - Mite Infections]]