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→Diagnosis
==Diagnosis==
==Diagnosis==
Virus isolation van be achieved by '''innoculation of goose or duck eggs''' from post-mortem samples. Mortality of the embryos occurs after 5-10 days and the '''livers become ochre coloured'''. Embryonic cell cultures can also be used for isolation. Intranuclear inclusions and suncytium formations can be seen on preparations of these primary cell cultures under microscopy.
Virus isolation van be achieved by '''innoculation of goose or duck eggs''' from post-mortem samples. Mortality of the embryos occurs after 5-10 days and the '''livers become ochre coloured'''. Embryonic cell cultures can also be used for isolation. Intranuclear inclusions and syncytium formations can be seen on preparations of these primary cell cultures under microscopy.
'''Immunofluorescence, electron microscopy, virus neutralisation, immunoperoxidase and indirect haemagglutination''' can then be used to confirm viral identity.
'''Immunofluorescence, electron microscopy, virus neutralisation, immunoperoxidase and indirect haemagglutination''' can then be used to confirm viral identity.
Where the clinical course has been more prolonged, a '''sero-fibrinous perihepatitis and pericarditis''' is common and large volumes of '''straw coloured ascites''' often found. '''Pulmonary oedema, liver lesions and catarrhal enteritis''' may also be present. '''Diptheritic lesions''' and ulcers may be seen in the mouth, pharynx and oesophagus – these are usually due to secondary infection.
Where the clinical course has been more prolonged, a '''sero-fibrinous perihepatitis and pericarditis''' is common and large volumes of '''straw coloured ascites''' often found. '''Pulmonary oedema, liver lesions and catarrhal enteritis''' may also be present. '''Diptheritic lesions''' and ulcers may be seen in the mouth, pharynx and oesophagus – these are usually due to secondary infection.
Histopathology reveals '''degenerative muocardial cell changes with loss of striation, fatty infiltration and intranuclear inclusion bodies'''. Similar changes are seen in intestinal and smooth muscle cells. Hepatocyte '''vacuolation and fatty infiltration''' dominate the liver. The hepatocytes also sometimes contain '''eosinophilic inclusion-like bodies'''. Pancreatic cells are often necrotic, shrunken and also infiltrated by fat deposits.
Histopathology reveals '''degenerative muocardial cell changes with loss of striation, fatty infiltration and intranuclear inclusion bodies'''. Similar changes are seen in intestinal and smooth muscle cells. Hepatocyte '''vacuolation and fatty infiltration''' dominate the liver. The hepatocytes also sometimes contain '''eosinophilic inclusion-like bodies'''. Pancreatic cells are often necrotic, shrunken and also infiltrated by fat deposits.
==Treatment==
==Treatment==