Changes

==Introduction==

==Introduction==

** Overall decreased absorptive capacity.  

** Overall decreased absorptive capacity.  

* The cellular infiltrate may result from:

* The cellular infiltrate may result from:

** Chronic inflammation (e.g. [[Johne's Disease)|Johnes disease]]).

** Chronic inflammation (e.g. [[Johne's Disease|Johnes disease]]).

** Immunologically mediated reactions (e.g. [[Intestines Inflammatory Bowel Disease And Related Conditions - Pathology#Eosinophilic Enteritis|eosinophilic enteropathy]]).

** Immunologically mediated reactions (e.g. [[Inflammatory Bowel Disease#Eosinophilic Enteritis|eosinophilic enteropathy]]).

** Neoplasia (e.g. [[Lymphoma|intestinal lymphoma]]).  

** Neoplasia (e.g. [[Lymphoma|intestinal lymphoma]]).  

* Inflammatory or reactive processes immediately below the epithelium may provoke interference with epithelial transport processes and increase the tendency to diarrhoea.

* Inflammatory or reactive processes immediately below the epithelium may provoke interference with epithelial transport processes and increase the tendency to diarrhoea.

==Diarrhoea in Small Intestinal Disease Only==

==Diarrhoea in Small Intestinal Disease Only==

* When disease is present only in the [[Small Intestine - Anatomy & Physiology|small intestine]], diarrhoea occurs only when the reserve capacity of the [[Colon - Anatomy & Physiology|colon]] to resorb water is exceeded.

* When disease is present only in the [[Small Intestine Overview - Anatomy & Physiology|small intestine]], diarrhoea occurs only when the reserve capacity of the [[Colon - Anatomy & Physiology|colon]] to resorb water is exceeded.

** The [[Colon - Anatomy & Physiology|colon]] is able to resorb up to 3-4 times the volume normally presented from the [[Small Intestine - Anatomy & Physiology|small intestine]].  

** The [[Colon - Anatomy & Physiology|colon]] is able to resorb up to 3-4 times the volume normally presented from the [[Small Intestine Overview - Anatomy & Physiology|small intestine]].  

* Therefore, for diarrhoea to occur, small intestinal disease must either:

* Therefore, for diarrhoea to occur, small intestinal disease must either:

** Be severe, or

** Be severe, or

** Interference with mucosal transport processes.

** Interference with mucosal transport processes.

** Destruction or loss of surface area.

** Destruction or loss of surface area.