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Endoparasiticides - Donkey (view source)
Revision as of 12:56, 6 December 2013
, 12:56, 6 December 2013no edit summary
The epidemiology, pathophysiology, clinical findings and treatment of parasitic infections in donkeys are described in detail in [[Parasites - Donkey|the parasite section]]. Further information on antiparasitic treatment of working donkeys outside the UK is given in [[Exotic Infections - Donkey]] section.
Three principal chemical classes of anthelmintics (macrocyclic lactones, benzimidazoles and tetrahydropyrimidines) are used most
Three principal chemical classes of anthelmintics (macrocyclic lactones, benzimidazoles and tetrahydropyrimidines) are used most
commonly.
commonly.
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Tetrahydropyrimidines (''e.g.''''' pyrantel embonate''') are active against adult and luminal stages of [[Strongyles - Donkey|strongyles]] and [[Ascarids - Donkey|ascarids]] but have only LIMITED efficacy against migrating larval parasites and NO activity against [[Bots - Donkey|bots]]. Double dose rates can be used to treat [[Tapeworm - Donkey|tapeworms]].
Tetrahydropyrimidines (''e.g.''''' pyrantel embonate''') are active against adult and luminal stages of [[Strongyles - Donkey|strongyles]] and [[Ascarids - Donkey|ascarids]] but have only LIMITED efficacy against migrating larval parasites and NO activity against [[Bots - Donkey|bots]]. Double dose rates can be used to treat [[Tapeworm - Donkey|tapeworms]].
==[[Anthelmintic Resistance|Resistance to anthelmintics]]==
Frequent use of [[Anthelmintic Drugs|anthelmintics]] and sub-optimal dosing has been implicated in the selection for resistant nematodes. Egg counts should be used as a guide to worming. Weigh the donkey or estimate its weight using the [[Heart Girth Nomogram - Donkey|nomogram]] to allow more accurate worm dosing.
Previous trials at [http://drupal.thedonkeysanctuary.org.uk/ the Donkey Sanctuary] suggest that resistance to the benzimidazole and pyrantel derivatives is developing. Recent trials have indicated that resistance to [[Macrocyclic Lactones|moxidectin]] may be developing. Future development in biological control using nematode-trapping fungi is being studied.
==Literature Search==
[[File:CABI logo.jpg|left|90px]]
Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).
<br><br><br>
[http://www.cabdirect.org/search.html?q=(title:(anthelmin*)+OR+subject:(anthelmin*)+OR+title:(endoparasiticide)+OR+subject:(endoparasiticides))+AND+(ab:(donkey)+OR+title:(donkey)+OR+od:(donkeys)) Anthelmintics in donkeys related publications]
==References==
==References==
* Horspool, L. (2008) Clinical pharmacology In Svendsen, E.D., Duncan, J. and Hadrill, D. (2008) ''The Professional Handbook of the Donkey'', 4th edition, Whittet Books, Chapter 12
* Horspool, L. (2008) Clinical pharmacology In Svendsen, E.D., Duncan, J. and Hadrill, D. (2008) ''The Professional Handbook of the Donkey'', 4th edition, Whittet Books, Chapter 12
* Trawford, A. and Getachew, M. (2008) Parasites In Svendsen, E.D., Duncan, J. and Hadrill, D. (2008) ''The Professional Handbook of the Donkey'', 4th edition, Whittet Books, Chapter 6
* Trawford, A.F. (2004). ‘Prescribing for donkeys’. ''The Veterinary Formulary. 6th edition''. Y. Bishop (ed). The Pharmaceutical Press, London.
* Trawford, A.F. (2004). ‘Prescribing for donkeys’. ''The Veterinary Formulary. 6th edition''. Y. Bishop (ed). The Pharmaceutical Press, London.
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|Maintitle = [[Sponsors#The Donkey Sanctuary|This section was sponsored and content provided by '''THE DONKEY SANCTUARY''']]
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[[Category:Donkey]]
[[Category:Pharmacology_-_Donkey]][[Category:Endoparasites_-_Donkey]]
[[Category:Parasites_-_Donkey]]