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Also known as: '''''Equine Flu'''''
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===Subtypes===
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== Introduction  ==
*Two subtypes of Equine Influenza have been described:
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**H7N7 (Equine 1), which was prevalent in the UK between 1963-1977
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**H3N8 (Equine 2), or the European strains, have been circulating since 1965
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*Some drift has occurred, causing outbreaks of North-American-like strains of H3N8 in 1998 (EU) and 2003 (South America)
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===Pathogenesis===
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*Aerosol and fomite transmission infects the epithelium of the upper respiratory tract, resulting in cell necrosis
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*This manifests a bronchiolitis and serous exudation
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*1-3 day incubation period
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*Excretion of the virus in nasal secretions peaks at 3-4 days and finishes by 10 days
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*Clinical signs:
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**Harsh dry cough
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**Pyrexia (103-106F)
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**Depression
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**Loss of appetite
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**Enlarged submandibular lymph nodes
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*Secondary bacterial infection can follow defective muco-ciliary transport, eg ''Streptococcus zooepidemicus''
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===Diagnosis===
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There are two subtypes of Equine Influenza described in the world today. These are:
*Virus isolation: Deep nasal swabs (12 inches) deposited into 10ml of transport medium and transported at 4C
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*Antigen detection via ELISA: tests for type A nucleoprotein
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*Serology provides a retrospective diagnosis by '''Haemagglutination Inhibition (HI)''':
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**Acute and Convalescent (2 weeks post-acute) samples are tested from the same animal
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**4-fold increase of HI must be shown to confirm diagnosis
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===Control===
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*Isolate coughing horses to minimize spread
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*Vaccination:
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**All vaccines include H7 and varieties of the current circulating strains of H3
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**'''Inactivated''' egg-grown vaccine is produced with alhydrogel as an adjuvant
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**'''Live''' vaccines using purified haemagglutinin do not require adjuvants
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**UK Jockey Club rules regarding timing:
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***Horses must be certified as completing a vaccination course of 3 injections at least 8 days prior to racing
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***The course consists of a primary inoculation followed by a second within 21-92 days and a third after a further 150-215 days
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***Boosters are given annually to maintain immunity, and in the event a year is missed the initial course of three jabs must be repeated
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*H7N7 (Equine 1), which was prevalent in the UK between 1963-1977
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*H3N8 (Equine 2), or the European strains, have been circulating since 1965.
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*Causative agent: [[Orthomyxoviridae]]
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*[[Rhinitis#Infectious causes of rhinitis|Rhinitis]],
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*Pathogenesis:
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**Inhalation -> replication in epithelial cells of upper and lower airways (attaches  via haemaglutinin spike and gains entry into cell) -> neuramidase alters efficiency of [[Respiratory System General Introduction - Pathology#Mucociliary escalator|mucociliary apparatus]]
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*Sloughing of the affected area
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*Severity of signs will depend on dose of virus
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*Acute [[Trachea Inflammatory - Pathology#Infectious causes of tracheitis|tracheo]][[Bronchi and Bronchioles Inflammatory - Pathology#Infectious causes of bronchitis or bronchiolitis|bronchitis]] with coughing, and fever
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*May be accompanied by secondary bacterial infections
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*No viraemia
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*In severe cases may cause [[Lungs Inflammatory - Pathology#Bronchointerstitial pneumonia|bronchointerstitial pneumonia]]
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*Secondary invaders are usually [[:Category:Streptococcus species|''Streptococci'']]
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[[Category:Orthomyxoviridae]][[Category:Horse Viruses]]
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Aerosol and fomite transmission infects the epithelium of the upper respiratory tract, resulting in cell necrosis, which then manifests as [[Bronchiolitis|bronchiolitis]] and serous exudation. There is a 1 - 3 day incubation period, with excretion of the virus in nasal secretions peaking at 3-4 days and finishing by 10 days.
[[Category:To_Do_-_Clinical/Viruses]]
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[[Category:Respiratory_Viral_Infections]]
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The disease usually occurs as an outbreak with many horses on the yard becoming infected. The most common age to encounter the disease is around 2 years and stress is a predisposing factor, so this disease is most commonly seen in racing yards.
[[Category:Respiratory Diseases - Horse]]
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== Clinical Signs ==
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There will be a harsh dry cough with pyrexia (39-41<sup>0></sup>C / 103-106F). The horse will appear generally depressed with a loss of appetite and decreased activity. Submandibular lymph nodes will be enlarged on physical examination. Secondary bacterial infection can follow defective muco-ciliary transport, eg ''[[Streptococcus zooepidemicus]]''.
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== Diagnosis ==
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Virus isolation by deep nasal swabs (12 inches) deposited into 10ml of transport medium and transported at 4<sup>0</sup>C. An antigen detection [[ELISA testing|ELISA]] should then be performed. Blood samples for serology should also be taken on day one of the disease (acute phase) and then two weeks later (convalescent stage). A 4-fold increase of haemaglutination inhibition (HI) must be shown to confirm diagnosis.
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== Treatment and Control ==
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Isolate coughing horses at once to minimize spread and perform thorough disinfection of all shared tack, stables, vehicles, boot and feed buckets. Treat any secondary bacterial infections with suitable antibiotics.
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Control for this disease is by [[Vaccines|vaccination]]. All vaccines include H7 and varieties of the current circulating strains of H3. There are strict rules from the Jockey Club regarding timing of vaccinations: Horses must be certified as completing a vaccination course of 3 injections at least 8 days prior to racing. The course consists of a primary inoculation followed by a second within '''21-92 '''days and a third after a further '''150-215 '''days. Boosters are given annually on or before the anniversary of the third injection to maintain immunity, and in the event a year is missed, the initial course of three injections must be repeated.
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== References ==
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Brown, C.M, Bertone, J.J. (2002) The 5-Minute Veterinary Consult- Equine', Lippincott, Williams &amp; Wilkins
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Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool
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Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) Equine Internal Medicine (Third Edition), Saunders.
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{{review}}
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{{OpenPages}}
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{{Learning |Vetstream = [https://www.vetstream.com/equis/Content/Disease/dis00586.asp Equine Influenza]}}
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[[Category:Orthomyxoviridae]] [[Category:Horse_Viruses]] [[Category:Expert_Review - Horse]] [[Category:Respiratory_Viral_Infections]] [[Category:Respiratory_Diseases_-_Horse]]
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