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Exocrine Pancreatic Insufficiency - Dog (view source)
Revision as of 16:53, 17 March 2022
, 16:53, 17 March 2022no edit summary
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==Description==
==Introduction==
The most common cause of [[Exocrine Pancreatic Insufficiency|Exocrine Pancreatic Insufficiency (EPI)]] in the dog is reported to be [[Pancreatic Atrophy, Exocrine| Pancreatic Acinar Atrophy (PAA)]].
The most common cause of [[Exocrine Pancreatic Insufficiency|Exocrine Pancreatic Insufficiency (EPI)]] in the dog is reported to be [[Pancreatic Atrophy, Exocrine| Pancreatic Acinar Atrophy (PAA)]].
===Laboratory Tests===
===Laboratory Tests===
Modest increases in Serum alanine aminotransferase (ALT) and a decrease in cholesterol concentration are seen on routine biochemical studies in some dogs. Serum concentrations of cobalamin may be low whilst serum folate concentrations may be high. Low serum concentrations of Vitamin E are also frequently documented in dogs with EPI.
Modest increases in Serum alanine aminotransferase (ALT) and a decrease in cholesterol concentration are seen on routine biochemical studies in some dogs. Serum concentrations of cobalamin may be low whilst serum folate concentrations may be high. Low serum concentrations of Vitamin E are also frequently documented in dogs with EPI.
The most sensitive and specific test for the diagnosis of EPI is the '''TLI''' serum assay. The values are greatly reduced as compared to normal animals. Values '''<2µg/l''' in dogs are considered diagnostic. This test must be carried out after withdrawing food for several hours.
The most sensitive and specific test for the diagnosis of EPI is the '''[[Exocrine Pancreatic Insufficiency|TLI]]''' serum assay. The values are greatly reduced as compared to normal animals. Values '''<2µg/l''' in dogs are considered diagnostic. This test must be carried out after withdrawing food for several hours.
===Other===
===Other===
==Prognosis==
==Prognosis==
EPI is generally irreversible and hence life-long treatment is needed. The prognosis is generally good as long the owner is aware of the longevity of the disease and the cost involved with treating it.
EPI is generally irreversible and hence life-long treatment is needed. The prognosis is generally good as long the owner is aware of the longevity of the disease and the cost involved with treating it.
{{Learning
|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Exocrine+Pancreatic+Insufficiency%22&occuring1=title&rowId=2&options2=AND&q2=dogs&occuring2=od&rowId=3&options3=AND&q3=&occuring3=freetext&x=57&y=10&publishedstart=yyyy&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Exocrine pancreatic insufficiency in dogs publications]
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==References==
==References==
Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''
Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''
Tams, T.R. (2003) '''Handbook of Small Animal Gastroenterology''' (2nd edition) Saunders.
Tams, T.R. (2003) '''Handbook of Small Animal Gastroenterology''' (2nd edition) Saunders.
[[Category:To_Do_-_Caz]]
For a list of EPI resources, treatment protocol, current EPI research and updates, along with an on-line support group for managing EPI, please visit '''[http://www.epi4dogs.com/ Epi4Dogs]''', a non-profit public charity EPI educational resource.
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[[Category:Expert Review]]
[[Category:Expert Review]]
[[Category:Dog]]
[[Category:Pancreatic Diseases - Dog]]