Changes

==Pathogenesis==

==Pathogenesis==

The severity of the infection is mainly dependent on the number of metacercariae ingested.  The Pathogenesis is often described as two-fold. The first stage occurring when the parasite migrates through the liver parenchyma, causing liver damage and haemorrhage.  The second phase occurs when the parasite is in the bile ducts, and damage is a result of the haematophagic activity of the adult flukes.

The severity of the infection is mainly dependent on the number of metacercariae ingested.  The pathogenesis is often described as two-fold. The first stage occurring when the parasite migrates through the liver parenchyma, causing liver damage and haemorrhage.  The second phase occurs when the parasite is in the bile ducts, and damage is a result of the haematophagic activity of the adult flukes.

==References==

==References==