Changes

Anthelmintic drugs are used in the control of fasciolosis. Not all flukicides are effective against each parasitic developmental stage, and so some may not be suitable for use in an outbreak of acute disease. Triclabendazole, a benzimidazole, is the flukicide with the broadest spectrum of activity against both immature and adult ''[[Fasciola hepatica]]'' and is therefore used to control acute disease. However, triclabendazole-resistant fluke populations are beginning to emerge. Albendazole, closantel, clorsulon and nitroxanyl all have a narrower spectrum of activity, primarily against adult fluke.

Anthelmintic drugs are used in the control of fasciolosis. Not all flukicides are effective against each parasitic developmental stage, and so some may not be suitable for use in an outbreak of acute disease. Triclabendazole, a benzimidazole, is the flukicide with the broadest spectrum of activity against both immature and adult ''[[Fasciola hepatica]]'' and is therefore used to control acute disease. However, triclabendazole-resistant fluke populations are beginning to emerge. Albendazole, closantel, clorsulon and nitroxanyl all have a narrower spectrum of activity, primarily against adult fluke.

There are two objectives to anthelmintic control of fluke in sheep and cattle. The first is to limit shedding of fluke eggs onto snail habitats, whcih is achieved by the use of any adulticidal drug in late winter/early spring. The second aim is to protect animals grazing metacercariae-contaminated pasture against fluke infection, and the approach to this is not so simplistic.

There are two objectives to anthelmintic control of fluke in sheep and cattle. The first is to limit shedding of fluke eggs onto snail habitats, whcih is achieved by the use of any adulticidal drug in late winter/early spring. The second aim is to protect animals grazing metacercariae-contaminated pasture against fluke infection, and the approach to this is not so simplistic. Here, the choice of drug, the timing of treatment and dosing interval is dependent on: a) whether acute or chronic disease is the (anticipated) problem; b) the likely intensity of challenge, based on local knowledge or fluke forecasting and c)the peristence of the selected drug.

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#The persistent effect of the drug (i.e. the  period after dosing, during which the animal is protected from  reinfection)

'''Vaccination'''   

'''Vaccination'''