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==Introduction==
==Introduction==
[[Image:Kinetics of FeLV 2.jpg|thumb|right|200px|Kinetics of FeLV - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]
[[Image:Kinetics of FeLV 2.jpg|thumb|right|200px|Kinetics of FeLV - Copyright Dr Brian Catchpole BVetMed PhD MRCVS]]
FeLV is an oncogenic retrovirus which causes neoplasia ([[Lymphoma|lymphoma]]), myelosuppression ([[Regenerative and Non-Regenerative Anaemias|anaemia]]) and immunosuppression (of [[Lymphocytes#T cells|T cells]]). Three different strains are currently recognised:
FeLV is an oncogenic mammalian type C retrovirus which causes neoplasia ([[Lymphoma|lymphoma]]), myelosuppression ([[Regenerative and Non-Regenerative Anaemias|anaemia]]) and immunosuppression (of [[Lymphocytes#T cells|T cells]]). Three different strains are currently recognised:
*FeLV-A -natural strain
*FeLV-A -natural strain
*FeLV-B which formed through FeLV-A recombining with endogenous retroviral sequences in the feline genome.
*FeLV-B which formed through FeLV-A recombining with endogenous retroviral sequences in the feline genome.
*'''Thymic lymphosarcoma''': T cell tumors, with only the thymus enlarged -this may result in dyspnoea and can be confirmed by radiography
*'''Thymic lymphosarcoma''': T cell tumors, with only the thymus enlarged -this may result in dyspnoea and can be confirmed by radiography
*'''Alimentary lymphosarcoma''': B cell tumors of the Peyer's patches
*'''Alimentary lymphosarcoma''': B cell tumors of the Peyer's patches
*Cutaneous horns on foot pads
*Epidermal and follicular epithelial hyperplasia, epidermal giant cells, dyskeratosis, necrosis, ulceration
FeLV-associated disease:
FeLV-associated disease:
There are 3 antigenic subgroups which are defined by the gp70 regulated viral response:
There are 3 antigenic subgroups which are defined by the gp70 regulated viral response:
*Group A is transmitted between cats and is monotypic: one vaccine covers all isolates. Infection with this viral subgroup leads to '''[[Lymphoma|lymphosarcoma]]'''.
*Group A is transmitted between cats and is monotypic: one vaccine covers all isolates. Infection with this viral subgroup leads to '''[[Lymphoma|lymphosarcoma]]'''.
*Group B is recombinant with transmissible FeLV-A; infection with viruses of this subgroup increases the chance of developing '''[[Thymus - Pathology|thymic tumours]]'''.
*Group B is recombinant with transmissible FeLV-A; infection with viruses of this subgroup increases the chance of developing '''[[Thymus Neoplasia|thymic tumours]]'''.
*Group C is a mutant of subgroup A. Isolates are rare, and occur as A+C mixes, leading to an increased chance of developing '''[[Regenerative and Non-Regenerative Anaemias|anaemia]]'''.
*Group C is a mutant of subgroup A. Isolates are rare, and occur as A+C mixes, leading to an increased chance of developing '''[[Regenerative and Non-Regenerative Anaemias|anaemia]]'''.
Where treatment is undertaken, anti-retroviral therapy is indicated with antibiotics to control secondary infections. Prevention is a key element in the control and treatment of FeLV overall.
Where treatment is undertaken, anti-retroviral therapy is indicated with antibiotics to control secondary infections. Prevention is a key element in the control and treatment of FeLV overall.
{{Learning
|Vetstream = [https://www.vetstream.com/felis/Content/Disease/dis60141 Feline leukemia virus disease]
}}
[[Category:Mammalian Type C retrovirus ]][[Category:Cat Viruses]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]][[Category:Alimentary Diseases - Cat]][[Category:Secondary Immunodeficiency]]
[[Category:Mammalian Type C retrovirus ]][[Category:Cat Viruses]][[Category:Lymphoreticular and Haematopoietic Diseases - Cat]][[Category:Alimentary Diseases - Cat]][[Category:Secondary Immunodeficiency]]
[[Category:Lymphoreticular and Haemopoietic Diseases]]
[[Category:Lymphoreticular and Haemopoietic Diseases]]
[[Category:Anaemia]]
[[Category:Anaemia|6]]
[[Category:Integumentary System - Viral Infections]]
[[Category:Integumentary System - Viral Infections]]