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Squamous cell carcinoma is the most common tumor of the equine stomach.<ref name="Olsen">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases.  ''Vet Rec'', 131:170-173.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref>.  It can affect the cardia and upper squamous regions of the stomach, resulting in a persistent mild [[Colic Diagnosis - Clinical Signs|colic]], commonly seen soon after feeding.  The tumor can invade and metastasize to lymph nodes, the lungs and regions palpable on [[Colic Diagnosis - Rectal Examination|rectal examination]].<ref name="Olsen">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases.  ''Vet Rec'', 131:170-173.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref>  The main clinical signs include '''weight loss''' and general ill health.(Merck)  '''Hypertrophic osteopathy''' associated with this neoplastic disease has been reported in one horse.<ref>Schleining, J.A, Voss, E.D (2004) Hypertophic osteopathy secondary to gastric squamous cell carcinoma in a horse.  ''Equine Vet Educ'', 16:304-307.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref>  Diagnosis is made by exclusion of other causes of weight loss and gastroscopy.  In most cases, surgical resection is not possible<ref>East, L.M, Savage, C.J (1998) Abdominal neoplasia (excluding urogenital tract).  ''Vet Clin North Am Equine Pract'', 14:475-493.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref> and the prognosis is grave.

Squamous cell carcinoma is the most common tumor of the equine stomach.<ref name="Olsen">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases.  ''Vet Rec'', 131:170-173.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref>.  It can affect the cardia and upper squamous regions of the stomach, resulting in a persistent mild [[Colic Diagnosis - Clinical Signs|colic]], commonly seen soon after feeding.  The tumor can invade and metastasize to lymph nodes, the lungs and regions palpable on [[Colic Diagnosis - Rectal Examination|rectal examination]].<ref name="Olsen">Olsen, S.N (1992) Squamous-cell carcinoma of the equine stomach: a report of 5 cases.  ''Vet Rec'', 131:170-173.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref>  The main clinical signs include '''weight loss''' and general ill health.(Merck)  '''Hypertrophic osteopathy''' associated with this neoplastic disease has been reported in one horse.<ref>Schleining, J.A, Voss, E.D (2004) Hypertophic osteopathy secondary to gastric squamous cell carcinoma in a horse.  ''Equine Vet Educ'', 16:304-307.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref>  Diagnosis is made by exclusion of other causes of weight loss and gastroscopy.  In most cases, surgical resection is not possible<ref>East, L.M, Savage, C.J (1998) Abdominal neoplasia (excluding urogenital tract).  ''Vet Clin North Am Equine Pract'', 14:475-493.  In: Zimmel, D.N (2010) ''Neoplasia of the Alimentary Tract'' in Reed, S.M, Bayly, W.M. and Sellon, D.C (2010) '''Equine Internal Medicine''' (Third Edition), ''Saunders'', Chapter 15.</ref> and the prognosis is grave.